Analysis of the HIF-1 activation upon infection with Bartonella henselae and other pathogens

汉赛巴尔通体和其他病原体感染后 HIF-1 激活分析

• 批准号: 5390246
• 负责人: Professor Dr. Volkhard A. J. Kempf
• 金额: --
• 依托单位: Institut für Medizinische Mikrobiologie und Krankenhaushygiene
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2002
• 资助国家: 德国
• 起止时间: 2001-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5390246?language=en
• 关键词: Analysis; HIF; activation; upon; infection

Bartonella henselae, a new emerging pathogen, is the causative agent of bacillary angiomatosis and peliosis, both of which are characterized by the proliferation of endothelial cells. B. henselae exhibits a tropism for endothelial cells in which the pathogen may invade, persist and replicate. By means of proteomics, reverse genetics, and cellular experiments we want to elucidate (i) what pathogenicity factors of B. henselae are expressed upon interaction with endothelial cells, (ii) how these factors contribute to invasion and intracellular persistence of B. henselae, and (iii) how these factors modulate the endothelial host cells. The results of these investigations will provide new insights into the molecular pathogenesis of B. henselae infections, and will demonstrate how facultative intracellular pathogens can modulate endothelial cells in order to ensure their habitate.

汉赛巴尔通体是一种新出现的病原体，可引起以内皮细胞增殖为特征的杆菌性血管瘤病和紫癜。B。henselae表现出对内皮细胞的嗜性，病原体可以在内皮细胞中侵入、持续存在和复制。通过蛋白质组学、反向遗传学和细胞实验，我们希望阐明（i）B的致病因子。henselae表达后与内皮细胞的相互作用，（ii）这些因素如何有助于入侵和细胞内持久性的B。henselae，以及（iii）这些因子如何调节内皮宿主细胞。这些研究结果将为B的分子发病机制提供新的见解。henselae感染，并将展示如何兼性细胞内病原体可以调节内皮细胞，以确保他们的栖息地。