Infection of endothelial progenitor cells with Bartonella henselae

汉塞巴尔通体感染内皮祖细胞

• 批准号: 5374659
• 负责人: Professor Dr. Volkhard A. J. Kempf
• 金额: --
• 依托单位: Institut für Medizinische Mikrobiologie und Krankenhaushygiene
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2002
• 资助国家: 德国
• 起止时间: 2001-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5374659?language=en
• 关键词: Infection; endothelial; progenitor; cells; Bartonella

Bartonella spp. causes cat-scratch disease, bacillary angiomatosis and trench fever. The facultative intracellular pathogen replicates within host cells efficiently. The bone marrow and the endothelial cells are discussed to represent the primary niche in the course of infection of Bartonella spp. We have shown that Bartonella spp. infect hematopoietic progenitor cells. It will be analyzed (i) whether Bartonella spp. persist and replicate within differentiating progenitor cells, (ii) whether and how intracellular Bartonella spp. modulate differentiation of hematopoietic progenitor cells and (iii) which bacterial genes are necessary for these processes. The results of our investigations should elucidate the molecular pathogenesis of Bartonella infections and should increase our understanding how intracellular bacteria in general modulate host cell functions to ensure their own habitat.

巴尔通体引起猫抓病、杆菌性血管瘤病和战壕热。兼性胞内病原体在宿主细胞内有效复制。骨髓和内皮细胞被认为是巴尔通体感染过程中的主要生态位。我们已经证明巴尔通体属。感染造血祖细胞。将分析（i）巴尔通体属（Bartonella spp.）持续和复制分化的祖细胞内，（ii）是否和如何细胞内巴尔通体属。调节造血祖细胞的分化和（iii）哪些细菌基因是这些过程所必需的。我们的调查结果应阐明巴尔通体感染的分子发病机制，并应增加我们的理解细胞内细菌一般如何调节宿主细胞的功能，以确保自己的栖息地。