Analysis of microRNAs and their target genes associated with phenotypes of oral squamous cell carcinomas.
Analysis of microRNAs and their target genes associated with phenotypes of oral squamous cell carcinomas.
批准号:
21659469
负责人:
YAMAMOTO Tetsuya
金额:
$2.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We investigated the expression of microRNAs in oral squamous cell carcinoma(OSCC) cell lines and normal oral keratinocytes by using microarray analysis and real time-PCR. It was demonstrated that the expression of 9 microRNAs was up-regulated and that of 13 microRNAs was down-regulated in OSCC cells compared with normal cells. We also revealed that miR-34a, one of down-regulated genes, acts as a tumor suppressor gene in OSCC cells and that the expression of the microRNA is down-regulated in OSCC tissues.
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ビスフォスフォネート投与と関連性があると考えられた顎骨骨髄炎ならびに顎骨壊死30症例に関する追跡調査~2年後の現状について~
30例被认为与双膦酸盐给药有关的骨髓炎和颌骨坏死病例的随访调查 - 2年后的现状 -
DOI:
--
发表时间:
2009
期刊:
日本口腔外科学会雑誌 55巻
影响因子:
--
作者:
[浦出雅裕, 田中徳昭, 嶋田淳, 柴田孝典, 古澤清文, 桐田忠昭, 山本哲也, 渡辺哲郎, 北川善政, 倉科憲治, 瀬戸宗一, 福田仁一]
通讯作者:
福田仁一
口腔扁平上皮癌細胞の放射線感受性に及ぼすマイクロRNAの影響に関する検討
microRNA对口腔鳞癌细胞放射敏感性影响的研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[吉村友秀, 笹部衣里, 葛化冰, 北村直也, 山本哲也]
通讯作者:
山本哲也
口腔扁平上皮癌におけるマイクロRNAの発現と増殖・浸潤における役割についての検討
口腔鳞状细胞癌中microRNA表达及其在增殖和侵袭中的作用研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[吉村友秀, 笹部衣里, 葛化冰, 北村直也, 山本哲也, 吉村友秀]
通讯作者:
吉村友秀
口腔外科学 (第3版)
口腔外科(第三版)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[林堂安貴, 他 (白砂兼光, 古郷幹彦 編)]
通讯作者:
古郷幹彦 編)
The down-regulated micro RNA in oral squamous cell carcinoma acts as a tumor suppressor
口腔鳞状细胞癌中下调的微小RNA充当肿瘤抑制因子
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tomohide Yoshimura, Ge Huabing, Wang Jianguo, Eri Sasabe, Tomohiro Yamada, Tetsuya Yamamoto]
通讯作者:
Tetsuya Yamamoto
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Development of Classification Apparatus for Nanoparticles Dispersed by Bead Milling with Electrophoresis
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Analysis of redox system regulating the expression of HIF-lα in squamous cell carcinomas
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Development of new glaucoma drugs wing experimental glaucoma models and clinical study on pertinence of modem glaucoma management
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The mechanism of escape from hypoxia-induced apoptosis in squamous cell carcinoma cells.
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Assessment of guide lines for glaucoma treatment and reestablishment of a new system for glaucoma management.
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GROWTH OF METASTATIC CACNER CELLS IN THE LYMPH NODES AND ITS REGULATION BY LYMPHOCYTES
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Establishment of therapeutic strategy for glaucomatous optic neuropathy
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依托单位:
Intracellular Signal Transduction in Oral Keratinocytes and Infiltrated Lymphocytes Obtained from Patients with Oral Lichen Planus-Biochemical Analysis of the Mechanism of Enhanced Cytokine Generation from Keratinocytes and Infiltration of Lymphocytes
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Clinical and Experimental Studies on Modification of Glaucoma Surgery
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依托单位:
海外基金