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Development of new glaucoma drugs wing experimental glaucoma models and clinical study on pertinence of modem glaucoma management

青光眼新药开发、实验性青光眼模型及现代青光眼治疗针对性的临床研究

基本信息

批准号：
17591828
负责人：
YAMAMOTO Tetsuya
金额：
$ 2.44万
依托单位：
Gifu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Basic research1. A new calpain inhibitor was Lund to have neuroprotective effect against NMDA-induced retinal ganglion cell damage.2. Several commercial anti-glaucoma drugs have anti-proliferative effect on cultured human conjunctival cells.3. Lomerizine, a calcium-channel blocker, was found. To have neuroprotective effect against retinal ganglion cell damage in a mouse model.4. Metallothionein also has neuroprotective effect against NMDA-induced retinal ganglion cell damage in a mouse model.5. Cobalt may induce selective loss of photoreceptor cells in mice.6. The role of tissue type plasminogen activator was investigated in relation with apoptosis of retina and optic nerve.Clinical research1. Prognosis of primary angle-closure/primary angle-closure glaucoma was analyzed. It was found that PAS extent and presence of GON were closely correlated with the poor prognosis.2. Anew method to analyze glaucomatous optic nerve pathology was established using a new stereo-fundus camera.3. Asymmetry of the second kernel response measured by multifocal ERG between nasal and temporal regions was found to be related with the degree of visual field deterioration in normal-tension glaucoma.4. It was Lund that sufficient IOP reduction significantly reduced the development of optic disc hemorrhages in both primary open-angle glaucoma and normal-tension glaucoma.5. We established basic data of 24-hr variation of IOP in normal-tension glaucoma.6. A population-based study found that the prevalence of total glaucoma was 5.0% and that of PACG to be 0.6% in Japanese aged 40 or older.7. Basic data on optic disc topography measured by Heidelberg Retina Tomograph were established in Japanese.8. An analysis on IOP reduction and aqueous outflow did not reveal definite relationship between IOP reduction by latanoprost and pretreatment tonographic C-value.

基础研究1。一种新的钙蛋白酶抑制剂隆德对NMDA诱导的视网膜神经节细胞损伤具有神经保护作用.几种市售抗青光眼药物对培养的人结膜细胞具有抗增殖作用.钙离子通道阻滞剂洛美利嗪对小鼠视网膜神经节细胞损伤具有神经保护作用.在小鼠模型中，金属硫蛋白对NMDA诱导的视网膜神经节细胞损伤也具有神经保护作用.钴可诱导小鼠感光细胞的选择性丧失.探讨组织型纤溶酶原激活剂在视网膜和视神经细胞凋亡中的作用。分析原发性闭角型/原发性闭角型青光眼的预后。结果发现PAS程度和GON的存在与肿瘤的预后不良密切相关.利用新型立体眼底照相机建立了一种分析青光眼视神经病变的新方法.多焦视网膜电图测量的第二核反应在鼻侧和颞侧区域的不对称性与正常眼压性青光眼的视野恶化程度有关.隆德认为，充分降低眼压可显著减少原发性开角型青光眼和正常眼压性青光眼视盘破裂的发生。建立正常眼压性青光眼24小时眼压变化的基础数据.一项基于人群的研究发现，在40岁或以上的日本人中，青光眼的总患病率为5.0%，PACG的患病率为0.6%。在日本建立了海德堡视网膜断层扫描仪测量视盘地形图的基础数据。对IOP降低和房水流出量的分析未显示拉坦前列素的IOP降低与治疗前张力图C值之间存在明确关系。