Assessment of guide lines for glaucoma treatment and reestablishment of a new system for glaucoma management.

点击翻译按钮获取中文摘要

Clinical research1.Regression analysis of visual field prognosis in normal-tension glaucoma found that the central field progresses more frequently in cases with previous history of disc hemorrhages as compared to cases without them.2.We have created a new analytical system using the Heidelberg Retina Tomograph (HRT) to observe the retinal nerve fiber layer more precisely.3.Follow-up HRT data of normal-tension glaucoma revealed that regression analysis of HRT parameters are useful in detecting the progression of glaucomatous optic neuropathy.4.We found in a population-based survey that the prevalence of disc hemorrhages is 0.6% per subject and 0.3% per eye.5.Nasally dominated optic disc change was found in normal-tension glaucoma cases with relatively lower intraocular pressure (IOP) by comparing the lower IOP subgroup with the higher, but still normal IOP subgroup.Basic research1.Using the models we established for rat neuroprotective study, a new drug, T-588 was found to have neuroprotective effect against retinal ganglion cell death caused by glaucomatous optic neuropathy.2.We found that tissue plasminogen activator is associated with NMDA-induced apoptosis using a knockout mouse model.3.Time course of NMDA-induced apoptosis was established using a mouse model.