Development of Innovative Methods for Analyzing Biological Molecules in Living Cells Based on Protein Chemistry

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Chemical understanding of biological process in living cells is an extremely important for the progress of science. This research project aimed to develop novel analytical methods for resolving complicate networks and function of biological molecules in living cells. We developed 1) molecular probes to visualize biological function in living cells, 2) methods to identify specific molecules in intracellular signaling, and 3) molecular probes to control a biological function with external light. The probes and imaging technologies will be useful for the analysis of biomolecules in the fields of basic biology and pharmacological science.