Preparation of bone-specific polymer biomaterials

为了制备骨特异性聚合物生物材料，我们合成了聚磷酸酯离聚体，并与双膦酸类化合物的基本作用进行了比较。聚磷酸酯离聚体在羟基磷灰石(HAP)微粒上的吸附量随聚磷酸酯中离子基团的增加而增加，离聚体与羟基磷灰石微粒的亲和力因钠盐的形成而增强。与帕米磷酸钠相比，聚磷酸酯离聚体能显著减少羟基磷灰石的生成。此外，聚磷酸酯离聚体的加入也降低了羟基磷灰石的吸收率。聚磷酸酯离聚体的细胞毒性明显低于帕米磷酸钠，聚磷酸酯离聚体的细胞相容性进一步提高。此外，还观察到与离聚体接触的小鼠成骨细胞碱性磷酸酶活性和矿物质沉积的增加。

In order to prepare bone specific polymer biomaterials, we have synthesized polyphosphoester ionomers and compared their fundamental actions with bisphosphonates. The adsorption amount of polyphosphoester ionomers on hydroxy apatite(HAp) microparticles was increased with an increase in the ionized units in polyphosphoesters and the affinity of ionomers for HAp microparticles was enhanced by formation of sodium salt. Polyphosphoesters ionomers could significantly reduce HAp-formation compared with pamidronate. Moreover, the resorption of HAp was also reduced with addition of polyphosphoester ionomers as a similar to pamidronate. The cytotoxicity of polyphosphoester ionomers was significantly lower than that of pamidronate and cell compatibility of the ionomer further improved by sodium salt formation of the polyphosphoester ionomers. Furthermore, the increment in ALP activity and mineral deposition of mouse osteoblast cells in contact with ionomers was observed.