Preparation of bone-specific polymer biomaterials

为了制备骨特异性高分子生物材料，我们合成了聚磷酸酯离聚体，并比较了它们与双膦酸盐的基本作用。聚磷酸酯离聚体在羟基磷灰石（HAp）微颗粒上的吸附量随着聚磷酸酯中离子单元的增加而增加，钠盐的形成增强了聚磷酸酯离聚体对羟基磷灰石微颗粒的亲和力。与帕米膦酸盐相比，聚磷酸酯离聚体可以显著减少hap的形成。此外，加入类似于帕米膦酸盐的聚磷酸酯离聚体也减少了羟基磷灰石的吸收。聚磷酸酯离聚体的细胞毒性明显低于帕米膦酸盐，并且通过钠盐的形成进一步提高了聚磷酸酯离聚体的细胞相容性。此外，我们还观察到与离聚体接触的小鼠成骨细胞ALP活性的增加和矿物质沉积。

In order to prepare bone specific polymer biomaterials, we have synthesized polyphosphoester ionomers and compared their fundamental actions with bisphosphonates. The adsorption amount of polyphosphoester ionomers on hydroxy apatite(HAp) microparticles was increased with an increase in the ionized units in polyphosphoesters and the affinity of ionomers for HAp microparticles was enhanced by formation of sodium salt. Polyphosphoesters ionomers could significantly reduce HAp-formation compared with pamidronate. Moreover, the resorption of HAp was also reduced with addition of polyphosphoester ionomers as a similar to pamidronate. The cytotoxicity of polyphosphoester ionomers was significantly lower than that of pamidronate and cell compatibility of the ionomer further improved by sodium salt formation of the polyphosphoester ionomers. Furthermore, the increment in ALP activity and mineral deposition of mouse osteoblast cells in contact with ionomers was observed.