Molecular basis of cholesterol efflux by ABCG1

ABCG_1和ABCG_4是一种脂质转运蛋白，可抑制β淀粉样蛋白的分泌，ABCG_1可刺激中枢神经元的轴突延伸。对纯化蛋白的分析表明，ABCG_1转运胆固醇和胆碱磷脂，而ABCG_4转运胆固醇。ABCG_1和ABCG_4分布于质膜上不同的区域，并通过调节区域结构来转运脂质。

It was demonstrated that ABCG_1 and ABCG_4 , a lipid transporter, suppress amyloidβsecretion and that ABCG_1 stimulates axonal extension of central nervous neurons. Analysis of purified proteins suggested that ABCG_1 transports cholesterol and choline phospholipid, while ABCG_4 transports cholesterol. It was also demonstrated that ABCG_1 and ABCG_4 distribute to distinct domains on the plasma membrane and transport lipid by modulating the domain structures.