Molecular mechanisms for neurogenesis and psychiatric dysfunction in postnatal and adult periods

我们发现肌动蛋白结合蛋白Girdin与DISC1结合，DISC1是精神分裂症的易感基因，并调节新生神经元在出生后和成年期间在海马齿状回的迁移和定位。此外，我们发现Girdin对于出生在脑室下区的神经母细胞的迁移是至关重要的。我们还研究了Girdin家族的两个成员Gipie和Daple的功能，发现它们分别调节内质网应激反应和Wnt信号通路。

We showed that the actin-binding protein Girdin binds to DISC1, a susceptibility gene for schizophrenia, and regulates the migration and positioning of newborn neurons in the dentate gyrus of the hippocampus during postnatal and adult periods. Furthermore, we identified that Girdin is crucial for the migration of neuroblasts born in the subventricular zone. We also studied the function of two members of the Girdin family of proteins, Gipie and Daple, and found that they regulate the ER stress response and the Wnt signaling pathway, respectively.