Molecular mechanisms for neurogenesis and psychiatric dysfunction in postnatal and adult periods

产后和成年期神经发生和精神功能障碍的分子机制

• 批准号: 21689013
• 负责人: ENOMOTO Atsushi
• 金额: $ 17.22万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689013/
• 关键词: 分子; 発生医学; Girdin; DISCI; 神経新生; 海馬; 統合失調症; DISC1

We showed that the actin-binding protein Girdin binds to DISC1, a susceptibility gene for schizophrenia, and regulates the migration and positioning of newborn neurons in the dentate gyrus of the hippocampus during postnatal and adult periods. Furthermore, we identified that Girdin is crucial for the migration of neuroblasts born in the subventricular zone. We also studied the function of two members of the Girdin family of proteins, Gipie and Daple, and found that they regulate the ER stress response and the Wnt signaling pathway, respectively.

我们发现，肌动蛋白结合蛋白Girdin结合DISC1，精神分裂症的易感基因，并调节新生神经元的迁移和定位在海马齿状回在出生后和成年期。此外，我们确定Girdin是在脑室下区出生的神经母细胞的迁移至关重要。我们还研究了Girdin蛋白家族的两个成员Gipie和Daple的功能，发现它们分别调节ER应激反应和Wnt信号通路。

项目成果

Girdin/GIV's partner Rabenosyn-5controls turnover of Akt

Girdin/GIV 的合作伙伴 Rabenosyn-5 控制 Akt 的营业额

• 发表时间: 2011
• 作者: Weng;L.;Enomoto;A.;Takahashi;M.
• 通讯作者: M.

A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size.

• DOI: 10.1016/j.yexcr.2009.06.019
• 发表时间: 2009-11
• 期刊: Experimental cell research
• 影响因子: 3.7
• 作者: Aekkachai Puseenam;Y. Yoshioka;R. Nagai;Reina Hashimoto;Osamu Suyari;M. Itoh;A. Enomoto;Masahide Takahashi;M. Yamaguchi

Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.

• DOI: 10.1091/mbc.e10-08-0724
• 发表时间: 2011-03-15
• 期刊: Molecular biology of the cell
• 影响因子: 3.3
• 作者: Matsushita E;Asai N;Enomoto A;Kawamoto Y;Kato T;Mii S;Maeda K;Shibata R;Hattori S;Hagikura M;Takahashi K;Sokabe M;Murakumo Y;Murohara T;Takahashi M
• 通讯作者: Takahashi M

プレスリリース「「海馬」形成の遺伝子特定」、中日新聞、2009年9月24日

新闻稿“鉴定负责‘海马’形成的基因”，中日新闻，2009 年 9 月 24 日

Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells

• DOI: 10.1111/j.1349-7006.2010.01520.x
• 发表时间: 2010-05-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Kurotsuchi, Ai;Murakumo, Yoshiki;Takahashi, Masahide
• 通讯作者: Takahashi, Masahide