Construction of a computational model for gait disorder using neuronal oscillators controlled by the cortico-basal ganglia loop

使用皮质基底神经节环控制的神经元振荡器构建步态障碍的计算模型

• 批准号: 21700353
• 负责人: OKAMOTO Tsuyoshi
• 金额: $ 2.33万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700353/
• 关键词: 計算論的神経科学; 歩行モデル; 歩行障害; パーキンソン病; 大脳基底核

In this study, we developed a computational model of human gait based on the cortico-basal ganglia loop circuit. The model reproduced gait patterns of normal subjects and patients with Parkinson' s disease(PD). First, we calculated quantitative indices on gait patterns, and characterized the differences between young healthy subjects and elderly healthy subjects and between elderly healthy subjects and elderly PD patients. Second, we constructed the computational model consisting of the cortico-basal ganglia loop and neuronal oscillators. The computer simulation using this model reproduced the gait motion of the legs of elderly healthy subjects and elderly PD patients, respectively. We confirmed that the cortico-basal ganglia loop could change the gait control.

在这项研究中，我们开发了一个基于皮质-基底节环路的人体步态计算模型。该模型再现了正常人和帕金森S病患者的步态模式。首先，我们计算了步态模式的量化指标，并刻画了年轻健康受试者与老年健康受试者以及老年健康受试者与老年帕金森病患者之间的差异。其次，我们构建了由皮质-基底节环和神经元振荡器组成的计算模型。利用该模型进行的计算机仿真，分别再现了老年健康受试者和老年帕金森病患者双腿的步态运动。我们证实皮质-基底节环可以改变步态控制。

项目成果

Clinical implication of short circuit in DBS

DBS 短路的临床意义

• 发表时间: 2012
• 作者: Miyagi Y;Samura K;Okamto T;Hayami T.
• 通讯作者: Hayami T.

パーキンソン病患者の定量的歩行評価

帕金森病患者的定量步态评估

• 发表时间: 2010
• 作者: 加藤成樹;小林憲太;深堀良二;小林和人;岡本剛
• 通讯作者: 岡本剛

Short circuit in deep brain stimulation.

脑深部刺激发生短路。

• DOI: 10.3171/2012.8.jns112073
• 发表时间: 2012
• 期刊: Journal of Neurosurgery
• 影响因子: 4.1
• 作者: K. Samura;Y. Miyagi;T. Okamoto;T. Hayami;J. Kishimoto;Mitsuo Katano;K. Kamikaseda
• 通讯作者: K. Kamikaseda

Three-dimensional Reconstruction of Human Brain Histological Section and the Development of Digital Brain Atlas of the Japanese

人脑组织切片三维重建及日本数字脑图谱开发

• 发表时间: 2011
• 期刊: Proceedings of the 3rd International Symposium on Digital Manufacturing
• 作者: Yasushi Miyagi;Kenichi Morooka;Takaichi Fukuda;Tsuyoshi Okamoto;Kenji Sunagawa;Xian Chen;Takehito Hayami.
• 通讯作者: Takehito Hayami.

Spectral analysis of field potential recordings by DBS electrode for localization of subthalamic nucleus in patients with Parkinson' s disease

DBS电极场电位记录频谱分析用于帕金森病患者丘脑底核定位

• 发表时间: 2009
• 期刊: Stereotactic and Functional Neurosurgery
• 影响因子: 1.7
• 作者: Yasushi Miyagi;Tsuyoshi Okamoto;Takato Morioka;Shozo Tobimatsu;Yoshitaka Nakanishi;Kazuyuki Aihara;Kimiaki Hashiguchi;Nobuya Murakami;Fumiaki Yoshida;Kazuhiro Samura;Shinji Nagata;Tomio Sasaki
• 通讯作者: Tomio Sasaki