Elucidation of the role of calpain on the degeneration of spines caused by diabetes using a low molecular weight compound

使用低分子量化合物阐明钙蛋白酶对糖尿病引起的脊柱变性的作用

• 批准号: 21700414
• 负责人: KOSUGE Yasuhiro
• 金额: $ 2.75万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700414/
• 关键词: 糖尿病; 海馬; スパイン; カルパイン; シナプス可塑性

Chronic hyperglycemia, such as diabetes mellitus, has been shown to induce cognitive impairment and defects of long-term potentiation in the hippocampus. In order to assess the mechanism of cognitive impairment by hyperglycemia, the expression of post-synaptic density 95 (PSD-95), a key components of spine, was investigated in a human neruoblastoma cell line, SH-SY5Y, after exposure to high-glucose and in the hippocampus in streptozotocin-induced diabetic mice. These results suggest that decrease in phosphorylated ERK plays a significant role in the adverse effect of chronic hyperglycemia in vivo and in vitro.

慢性高血糖症，如糖尿病，已被证明可诱导认知功能障碍和海马长时程增强功能缺陷。为了探讨高血糖导致认知功能障碍的机制，研究了高糖对人神经母细胞瘤细胞系SH-SY 5 Y和链脲佐菌素诱导的糖尿病小鼠海马中突触后密度95（post-synaptic density 95，PSD-95）表达的影响。这些结果表明，磷酸化ERK的减少在体内和体外慢性高血糖的不利影响中起着重要作用。

项目成果

ストレプトゾトシン誘発糖尿病マウス海馬における細胞内シグナル伝達系の変化

链脲佐菌素诱导糖尿病小鼠海马细胞内信号转导系统的变化

• 发表时间: 2010
• 作者: 小菅康弘;川島由樹;山岡由佳;山岸由佳;宮岸寛子;石毛久美子;伊藤芳久
• 通讯作者: 伊藤芳久

Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice

• DOI: 10.1016/j.neulet.2009.03.017
• 发表时间: 2009-04-24
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Kosuge, Yasuhiro;Sekikawa-Nishida, Kayo;Ito, Yoshihisa
• 通讯作者: Ito, Yoshihisa