Development of 3D-fibrous scaffolds with ability of stimulating mesenchymal stem cells

开发了具有三维结构的新型纤维材料，用于组织工程领域。将释放硅酸盐离子的陶瓷颗粒与生物可降解聚合物结合，制备出促进细胞增殖和矿化的纤维材料。所制备的纤维材料具有柔韧性和弹性。细胞培养试验结果显示，成骨细胞样细胞在材料的纤维结构内增殖。

Novel fibrous materials with three dimensional structure were developed for use in the tissue engineering field. Ceramic particles releasing silicate ions, which have been reported to stimulate cell functions, were combined with biodegradable polymer to prepare fibrous materials enhancing cell proliferation and mineralization. The prepared fibrous materials showed flexibility and elasticity. Results of cell culture tests for the materials showed osteoblast-like cells proliferated inside of the fibrous structure of the materials.