A multifaceted approach to elucidate the associations of genetic polymorphisms and lifestyle factors with autonomic nervous system function.

自主神经系统(ANS)活性低下与心血管或代谢性疾病的发生发展密切相关。遗传和环境因素都与ANS功能低下有错综复杂的关系。因此，对这些因素进行多方面的分析，有助于建立个性化的药物或营养。目前的研究表明，瘦素、瘦素受体、Ghrelin和生长激素促分泌素受体的基因多态性与ANS活性、能量摄入、胃动力、血压或体重的差异显著相关。这些观察结果表明，研究的基因多态可能是相关疾病的潜在风险。

Hypoactivity of autonomic nervous system (ANS) is closely associated with pathogenesis and progress of cardiovascular or metabolic diseases. Both genetic and environmental factors are intricately related to the hypofunction of ANS. Therefore, multifaceted analyses of these factors can contribute to establishment of the personalized medicine or nutrition. Present study showed that the genetic polymorphisms of leptin, leptin receptor, ghrelin, and growth hormone secretagogue receptor are significantly associated with differences in ANS activity, energy intake, gastric motility, blood pressure, or body weight. These observations suggest that studied polymorphisms may be potential risk of related diseases.