A multifaceted approach to elucidate the associations of genetic polymorphisms and lifestyle factors with autonomic nervous system function.

采用多方面的方法来阐明遗传多态性和生活方式因素与自主神经系统功能的关联。

• 批准号: 21700691
• 负责人: MATSUNAGA Tetsuro
• 金额: $ 2.83万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700691/
• 关键词: 遺伝子多型; 自律神経; 心拍変動; 胃運動; 胃電図; 食習慣; 栄養; 生活習慣病; グレリン; グレリン受容体; エネルギー; レプチン; レプチン受容体

Hypoactivity of autonomic nervous system (ANS) is closely associated with pathogenesis and progress of cardiovascular or metabolic diseases. Both genetic and environmental factors are intricately related to the hypofunction of ANS. Therefore, multifaceted analyses of these factors can contribute to establishment of the personalized medicine or nutrition. Present study showed that the genetic polymorphisms of leptin, leptin receptor, ghrelin, and growth hormone secretagogue receptor are significantly associated with differences in ANS activity, energy intake, gastric motility, blood pressure, or body weight. These observations suggest that studied polymorphisms may be potential risk of related diseases.

自主神经系统（ANS）功能低下与心血管或代谢疾病的发病和进展密切相关。遗传和环境因素都与 ANS 功能低下密切相关。因此，对这些因素的多方面分析有助于建立个性化医疗或营养。目前的研究表明，瘦素、瘦素受体、生长素释放肽和生长激素促分泌素受体的基因多态性与ANS活性、能量摄入、胃动力、血压或体重的差异显着相关。这些观察结果表明，所研究的多态性可能是相关疾病的潜在风险。

项目成果

Association of estrogen receptor-alpha polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males.

健康年轻日本男性雌激素受体-α 多态性与心脏自主神经活动的关联。

• 发表时间: 2010
• 期刊: Clinica Chimica Acta 411
• 作者: Tetsuro Matsunaga;Ning Gu;Hanae Yamazaki;Tetsuya Adachi;Koichiro Yasuda;Toshio Moritani;Kinsuke Tsuda;Tohru Nishiyama;Masahiko Nonaka
• 通讯作者: Masahiko Nonaka

グレリンLeu72Met多型とエネルギー摂取量

Ghrelin Leu72Met 多态性与能量摄入

• 发表时间: 2009
• 作者: M Sakuma;et al.;松永哲郎
• 通讯作者: 松永哲郎

レプチンおよびレプチン受容体における遺伝子多型と自律神経活動

瘦素和瘦素受体的遗传多态性和自主神经活动

• 发表时间: 2010
• 作者: 重松良祐;中西礼;藤井久美子;堀内咲子;松永哲郎
• 通讯作者: 松永哲郎

レプチンおよびレプチン受容体における遺伝子多型と自律神経活動、胃運動機能との関連解析

瘦素及瘦素受体基因多态性与自主神经活动及胃运动功能的关系分析

• 发表时间: 2010
• 作者: Sun Q;Hirasawa A;Hara T;Kimura I;Adachi T;Awaji T;Ishiguro M;Suzuki T;Miyata N;Tsujimoto G.;松永哲郎
• 通讯作者: 松永哲郎

Association of estrogen receptor-α gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males

• DOI: 10.1016/j.cca.2009.12.028
• 发表时间: 2010-04-02
• 期刊: CLINICA CHIMICA ACTA
• 影响因子: 5
• 作者: Matsunaga, Tetsuro;Gu, Ning;Nonaka, Masahiko
• 通讯作者: Nonaka, Masahiko