Association of genetic polymorphisms and lifestyle factors with postprandial autonomic nervous response and gastric motility

自主神经系统功能障碍和胃运动功能障碍分别与心血管代谢疾病和功能性胃功能障碍密切相关。本研究利用心率变异性分析和胃电图研究了年轻健康受试者的遗传多态性（胃饥饿素、生长激素促分泌受体、胆囊收缩素受体和g蛋白β3亚基（GNB3））和生活方式因素（体力活动和饮食习惯）与餐后自主神经反应和胃动力的关系。本研究表明，体重指数、血压、胃饥饿素和GNB3基因多态性与餐后胃动力独立相关。此外，本研究还探讨了咖啡摄入对年轻健康受试者胃运动和自主神经活动的影响。结果表明，咖啡摄入可以增强胃动力和自主神经活动，而这些影响在不习惯和习惯喝咖啡的人之间是不同的。

Hypofunction of autonomic nervous system and gastric motility is closely related to cardiovascular and metabolic diseases and functional gastric disorder, respectively. This study investigated the association of genetic polymorphisms (ghrelin, growth hormone secretagogue receptor, cholecystokinin receptor, and G-proten β3 subunit(GNB3)) and lifestyle factors (physical activity and dietary habit) with postprandial autonomic nervous response and gastric motility using heart rate variability analysis and electrogastrography in young healthy subjects. The present study showed that body mass index, blood pressure, and polymorphisms in ghrelin and GNB3 genes were independently associated with postprandial gastric motility. In addition, present study investigated the effects of coffee intake on gastric motility and autonomic nervous activity in young healthy subjects. Results suggest that coffee intake enhances gastric motility and autonomic nervous activity, and these effects are different between non-habitual and habitual coffee drinkers.