Regulatory mechanism of insulin secretion system by coenzyme Q_<10>

辅酶Q_<10>对胰岛素分泌系统的调节机制

• 批准号: 21700709
• 负责人: OKUNO Masaaki
• 金额: $ 2.83万
• 依托单位: Kobe Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700709/
• 关键词: コエンザイムQ10; 糖尿病; インスリン分泌; 酸化ストレス; 膵ss細胞; アポトーシス; 抗酸化作用; ATP; 膵β細胞; コエンザイムQ_<10>

Coenzyme Q10 (CoQ_<10>) is the endogenous substance possessing 2 physiological actions : ATP production-activating and antioxidative actions. Both actions are assumed to play important roles in the exhibition and maintenance of pancreatic ss-cell function. To demonstrate this hypothesis, the role of CoQ10 in the insulin secretion system was investigated.When sodium selenite was added at a high concentration to induce oxidative stress in RIN5F cells, a rat-derived pancreatic ss-cell line, most cells died within 24 hours. However, when cells were pretreated with CoQ10, this cytopathy was markedly inhibited. When the CoQ10 synthesis pathway was enhanced or inhibited, the expression of genes involved in insulin secretion altered. On the other hand, the CoQ10 content was decreased in the pancreas of type 1 diabetic rats in which pancreatic ss-cells were partially destroyed induced by streptozototocin, but it returned close to the normal level in animals in which the diabetic condition was improved. These findings suggest that CoQ10 plays an important role in the protection of pancreatic ss-cells and the insulin secretion system.

辅酶Q10（COQ_ <10>）是具有2种生理作用的内源物质：ATP生产激活和抗氧化作用。假定这两种动作都在胰腺SS细胞功能的展览和维护中起着重要作用。为了证明这一假设，研究了CoQ10在胰岛素分泌系统中的作用。当以高浓度添加亚硒酸钠以在RIN5F细胞中诱导氧化应激时，大多数细胞在24小时内死亡。但是，当细胞用COQ10预处理时，该细胞病被明显抑制。当CoQ10合成途径增强或抑制时，胰岛素分泌中涉及的基因的表达改变了。另一方面，在1型糖尿病大鼠的胰腺中，COQ10含量减少，其中胰腺链球菌素会部分破坏胰腺SS细胞，但链蛋白酶诱导，但它接近改善糖尿病状况的动物的正常水平。这些发现表明，COQ10在保护胰腺SS细胞和胰岛素分泌系统中起着重要作用。

项目成果

Distribution of Oxidized and Reduced Forms of Coenzyme Q Homologues in Japanese Foods

日本食品中氧化型和还原型辅酶 Q 同系物的分布

• 发表时间: 2009
• 作者: M.Okuno;A.Kettawan;C.Kunthida;S.Fujita;D.Takechi;T.Takahashi;T.Kishi;T.Okamoto
• 通讯作者: T.Okamoto

コエンザイムQ10による白内障発症予防効果

辅酶Q10对白内障的预防作用

• 发表时间: 2010
• 作者: 奥野正顕;藤田翔;武智大志;岡本正志
• 通讯作者: 岡本正志

コエンザイムQ10による白内障発症防御作用

辅酶Q10对白内障发生的保护作用

• 发表时间: 2009
• 作者: 奥野正顕;藤田翔;武智大志;高橋隆幸;紀氏健雄;岡本正志
• 通讯作者: 岡本正志

コエンザイムQ10による白内障発症予防効果とその作用機序

辅酶Q10预防白内障的作用及其作用机制

• 发表时间: 2010
• 作者: 奥野正顕;武智大志;藤田翔;高橋隆幸;岡本正志
• 通讯作者: 岡本正志