Effect of plant polyphenols on oxidative stress and lipid metabolism in pregnancy-induced hypertension rat models

为了研究植物多酚对妊娠高血压大鼠模型孕妇血压、氧化应激和糖脂代谢的影响，采用一氧化氮合酶抑制剂或过量摄入果糖治疗妊娠大鼠。在一氧化氮缺乏的妊娠大鼠中，红豆多酚显著上调肾中锰超氧化物歧化酶的表达，但未观察到母体血压显著降低。在果糖喂养的妊娠大鼠中，红豆多酚部分降低了肝脏脂肪生成转录因子的表达

In order to examine the effect of plant polyphenols on maternal blood pressure, oxidative stress, and glucose and lipid metabolism in pregnancy-induced hypertension rat models, pregnant rats were treated by nitric oxide(NO) synthase inhibitor or excess intake of fructose. In NO-deficient pregnant rats, azuki bean polyphenols up-regulated significantly renal expression of Mn-superoxide dismutase, although significant decrease in maternal blood pressure was not observed. In fructose-fed pregnant rats, azuki bean polyphenols partly diminished hepatic expression of lipogenic transcription factor