Effect of plant polyphenols on oxidative stress and lipid metabolism in pregnancy-induced hypertension rat models

为探讨植物多酚对妊娠高血压大鼠模型母体血压、氧化应激及糖脂代谢的影响，采用一氧化氮合酶（NO）抑制剂或过量摄入果糖对妊娠大鼠进行干预。在NO缺乏的孕鼠，红豆多酚上调肾脏锰超氧化物歧化酶的表达显着，虽然没有观察到显着降低母体血压。在果糖喂养的孕鼠中，红豆多酚部分降低肝脏脂肪生成转录因子的表达

In order to examine the effect of plant polyphenols on maternal blood pressure, oxidative stress, and glucose and lipid metabolism in pregnancy-induced hypertension rat models, pregnant rats were treated by nitric oxide(NO) synthase inhibitor or excess intake of fructose. In NO-deficient pregnant rats, azuki bean polyphenols up-regulated significantly renal expression of Mn-superoxide dismutase, although significant decrease in maternal blood pressure was not observed. In fructose-fed pregnant rats, azuki bean polyphenols partly diminished hepatic expression of lipogenic transcription factor