Total synthesis of a natural HIV protease inhibitor and its partial structures

HIV蛋白酶是一种酶，负责对逆转录病毒表达的多蛋白进行蛋白分解，以产生增殖和感染所需的成熟蛋白。因此，抑制HIV蛋白水解酶对于HIV感染者来说是一种重要的治疗策略。在本研究中，我们研究了海洋天然产物二异氰酸酯及其部分结构的合成路线。我们已经完成了双缩酮B的C_1-C_(11)非环区和C_9-C_(28)螺缩区的立体选择性合成。

HIV protease is an enzyme responsible for the proteolysis of the polyprotein expressed by the retrovirus to produce matured proteins necessary for proliferation and infection. Thus, the inhibition of HIV protease represents an important therapeutic strategy for HIV-infected patients. In the present study, we have investigated synthetic routes toward marine natural products didemnaketals and their partial structures. We have completed the stereoselective syntheses of the C1-C11 acyclic domain and C9-C28 spiroacetal domain of didemnaketal B.