Synthetic Approach toward the Structural Elucidation of the Anti-HIV Active Compound Symbiodinolide

从海洋中获得的有机化合物，即所谓的海洋天然产物，由于其多样而有效的生物活性，作为药物候选化合物受到了广泛的关注。共生生物内酯是一种分子量为2860的海洋天然多元醇类化合物，具有钙通道开放活性和抗HIV活性。因此，该分子有望作为一种新型药物加以利用。本研究对共生物内酯进行了结构解析的合成研究，合成了与其半分子对应的片段，并对其结构进行了测定。

Organic compounds obtained from the ocean, so-called marine natural products, have received remarkable attention as drug candidate compounds due to their diverse and potent biological activities. Symbiodinolide, the polyol marine natural product with a molecular weight of 2860, has calcium channel opening activity and anti-HIV activity. Therefore, this molecule has been expected to be utilized as the novel medicine. In this research, synthetic study of symbiodinolide toward the structural elucidation has been performed, which has resulted in the synthesis and structural determination of the fragments corresponding to the half of the molecule.