本项目拟在申请人前期研究工作的基础上，针对各种天然物和药物的结构，基于炔丙醇为原料，系统地研究构建这些化合物骨架的新合成方法，进而将这些新合成方法应用于若干天然物和药物的全合成，包括：Lamellarin系列天然产物；(S)-Monastrol；(S)-L-771688；Naamidine系列天然产物；Meridianin系列天然物等；以及药物Cibenzoline Succinate；Prenoxdiazin；Octocrylene；Gleevec；Rosuvastatin Calciu；Molindone等的全合成，拟研究的这些新合成方法涉及：不对称亲核取代反应、立体选择性环合反应和重排反应等，这些新合成方法具有原创性和申请人实验室的研究特色。天然物和药物的全合成设计，以及基于炔丙醇的新合成方法研究中，筛选出合适有效的催化剂，包括它的配体和反应添加剂，是本项目拟解决的关键问题。

Based on the prophase research of us, new synthetic methods using propargyl alcohol as the raw materials, will be researched systematically and deeply on the construction of some natural products and drugs. Total synthesis of several natrual products and drugs will also be researched, based on these new synthetic methods, including synthesis of the natural products: Lamellarin series, (S)-Monastrol, (S)-L-771688, Naamidine series and Meridianin series, as well as several drugs: Cibenzoline Succinate, Prenoxdiazin, Octocrylene, Gleevec, Rosuvastatin Calciu and Molindone. These new synthetic methods, which have original creativity and also are the unique feature of our lab, include asymmetric nucleophilic substitution reaction, stereo selective cyclization, and rearrangement reaction and so on. Screening appropriate and effective catalysts including their ligands and reaction additives will be the key problem needed to be solved.