Creation of polymeric contrast agent systems possessing multiple imaging modalities

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In this study, we have designed polymer-based contrast agent carrier systems that can be applied in multiple imaging modalities;MRI, PET, SPECT, and ultrasound. Using a polymeric micelle MRI contrast agent, we succeeded in targeting to murine solid tumors and obtained substantial enhancementsof image contrast at the tumor sites. Additionally, this polymeric micelle contrast agent did not show any ABC phenomenon. Since the ABC phenomenon is seriously detrimental to multiple doses of contrast agents, this fact indicates a very high value of the polymeric micelle contrast agent in clinical use.