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Sonodynamic cancer therapy with tumor targeting TiO_2 nanoparticles.

Sonodynamic cancer therapy with tumor targeting TiO_2 nanoparticles.
使用肿瘤靶向 TiO_2 纳米颗粒进行声动力癌症治疗。
批准号:
22300177
负责人:
SHIMIZU Nobuaki
金额:
$11.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
A new sonodynamic therapy for cancer cells was proposed in this study. The delivery of titanium dioxide (TiO2) nanoparticles (NPs) modified with avidinspecifically recognizing cancer cells and subsequent generation of OH radicals from TiO2 NPs activated by external ultrasound irradiation were studied. The uptake of TiO2 NPs modified with avidin by MCF7 cells was clarified and apoptosis was observed at 6 h after the TiO2/US treatment. Although no apparent cell-injury was observed until 24 h after the treatment, the viable cell concentration had deteriorated to 46% of the control at 96 h.
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [田下裕之, 仁宮一章, 清水宣明]
通讯作者: 清水宣明
Ultrasound-induced cell damage and membrane lipid peroxidation of Escherichia coli in the presence of non-woven TiO_2 fabrics.
TiO_2 无纺布存在下超声诱导大肠杆菌细胞损伤和膜脂过氧化。
DOI: --
发表时间: 2010
期刊: Ultrason.Sonochem
影响因子: --
作者: [Mohamad Mizanur Rahman, Kazuaki Ninomiya, Chiaki Ogino, Nobuaki Shimizu]
通讯作者: Nobuaki Shimizu
DOI: 10.1016/j.bmcl.2010.06.124
发表时间: 2010-09
期刊: Bioorganic & medicinal chemistry letters
影响因子: 2.7
作者: [C. Ogino;N. Shibata;R. Sasai;K. Takaki;Y. Miyachi;S. Kuroda;K. Ninomiya;N. Shimizu]
通讯作者: C. Ogino;N. Shibata;R. Sasai;K. Takaki;Y. Miyachi;S. Kuroda;K. Ninomiya;N. Shimizu
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [仁宮一章, 川嶋聡, 金田壱彦, 荻野千秋, 清水宣明]
通讯作者: 清水宣明
34
    Targeted sonocatalytic cancer cell injury using avidin-conjugated titanium dioxide nanoparticles
    • 批准号:
      24650294
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      SHIMIZU Nobuaki
    • 依托单位:
    Establishment of continuous base for study and education to prevent influenza pandemic in district areas
    Sonodynamic cancer therapy with molecular target TiO2 nano-particles
    • 批准号:
      19300182
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.98万
    • 财政年份:
      2007
    • 负责人:
      SHIMIZU Nobuaki
    • 依托单位:
    An environmental assurance system by catalytic ultrasonic irradiation with functional TiO2 particles.
    • 批准号:
      16310055
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.79万
    • 财政年份:
      2004
    • 负责人:
      SHIMIZU Nobuaki
    • 依托单位: