Sonodynamic cancer therapy with tumor targeting TiO_2 nanoparticles.
Sonodynamic cancer therapy with tumor targeting TiO_2 nanoparticles.
批准号:
22300177
负责人:
SHIMIZU Nobuaki
金额:
$11.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
A new sonodynamic therapy for cancer cells was proposed in this study. The delivery of titanium dioxide (TiO2) nanoparticles (NPs) modified with avidinspecifically recognizing cancer cells and subsequent generation of OH radicals from TiO2 NPs activated by external ultrasound irradiation were studied. The uptake of TiO2 NPs modified with avidin by MCF7 cells was clarified and apoptosis was observed at 6 h after the TiO2/US treatment. Although no apparent cell-injury was observed until 24 h after the treatment, the viable cell concentration had deteriorated to 46% of the control at 96 h.
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超音波刺激応答型リボソームを用いたドラッグデリバリーシステムの構築
使用超声刺激响应核糖体构建药物递送系统
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[田下裕之, 仁宮一章, 清水宣明]
通讯作者:
清水宣明
Ultrasound-induced cell damage and membrane lipid peroxidation of Escherichia coli in the presence of non-woven TiO_2 fabrics.
TiO_2 无纺布存在下超声诱导大肠杆菌细胞损伤和膜脂过氧化。
DOI:
--
发表时间:
2010
期刊:
Ultrason.Sonochem
影响因子:
--
作者:
[Mohamad Mizanur Rahman, Kazuaki Ninomiya, Chiaki Ogino, Nobuaki Shimizu]
通讯作者:
Nobuaki Shimizu
DOI:
10.1016/j.bmcl.2010.06.124
发表时间:
2010-09
期刊:
Bioorganic & medicinal chemistry letters
影响因子:
2.7
作者:
[C. Ogino;N. Shibata;R. Sasai;K. Takaki;Y. Miyachi;S. Kuroda;K. Ninomiya;N. Shimizu]
通讯作者:
C. Ogino;N. Shibata;R. Sasai;K. Takaki;Y. Miyachi;S. Kuroda;K. Ninomiya;N. Shimizu
Cell-SELEX法によるがん細胞に対するDNA アプタマーの選抜とその特性評価
Cell-SELEX法筛选抗癌细胞DNA适体并评价其特性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[仁宮一章, 川嶋聡, 金田壱彦, 荻野千秋, 清水宣明]
通讯作者:
清水宣明
分子標的ナノ粒子による超音波力学的がん治療
使用分子靶向纳米颗粒进行超声波机械癌症治疗
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[M. Yokoyama, K. Shiraishi, K. Kawano, Y. Maitani, 岩崎永子,森山達也,浅井歩,獅子谷卓,吉澤晋,梅村晋一郎, Sachiko Mogami, 清水宣明]
通讯作者:
清水宣明
共 34 条
Targeted sonocatalytic cancer cell injury using avidin-conjugated titanium dioxide nanoparticles
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批准号:24650294
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2012
-
负责人:SHIMIZU Nobuaki
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依托单位:
Establishment of continuous base for study and education to prevent influenza pandemic in district areas
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批准号:23659250
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.5万
-
财政年份:2011
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负责人:SHIMIZU Nobuaki
-
依托单位:
Sonodynamic cancer therapy with molecular target TiO2 nano-particles
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批准号:19300182
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2007
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负责人:SHIMIZU Nobuaki
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依托单位:
An environmental assurance system by catalytic ultrasonic irradiation with functional TiO2 particles.
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批准号:16310055
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.79万
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财政年份:2004
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负责人:SHIMIZU Nobuaki
-
依托单位:
Identification of novel coreceptors in GPCRs harboring several tyrosines in the N'-terminal region
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批准号:14370099
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.97万
-
财政年份:2002
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负责人:SHIMIZU Nobuaki
-
依托单位:
Identification of the functional domains in an orphan G protein-coupled receptor, GPR1, which acts as a coreceptor for the brain-derived cell tropism of HIV-1, HIV-2, and SIV
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批准号:12470068
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.2万
-
财政年份:2000
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负责人:SHIMIZU Nobuaki
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依托单位:
Bio-affinity Chemical Sensors for in Vivo Monitoring of Bio-active Substances
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批准号:10557006
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项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$8.19万
-
财政年份:1998
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负责人:SHIMIZU Nobuaki
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依托单位:
Functional correlations between hypothalamus and splenic sympathetic nervous system under environmental stress and immune response
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批准号:10470015
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$3.84万
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财政年份:1998
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负责人:SHIMIZU Nobuaki
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依托单位:
Characteristics of the Multifunctional Biosensors for the Measurements of Bioactive Substances in the Living Body
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批准号:05558115
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$10.56万
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财政年份:1993
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负责人:SHIMIZU Nobuaki
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依托单位:
Study of the biochemical processing of the biowarning information through the hypothalamu
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批准号:04670095
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1992
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负责人:SHIMIZU Nobuaki
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依托单位:
Hypothalamic modulation of the biowarning processes caused by the emotional stress
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批准号:02670069
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.38万
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财政年份:1990
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负责人:SHIMIZU Nobuaki
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依托单位:
Integration of the biowarning information through the hypothalamic neuronal network.
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批准号:63480470
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.33万
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财政年份:1988
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负责人:SHIMIZU Nobuaki
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依托单位:
Multifunctional biosensors for analysis of brain functions with measurements of bioactive substances in the brain.
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批准号:61870102
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$17.6万
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财政年份:1986
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负责人:SHIMIZU Nobuaki
-
依托单位: