Development of high stable biodegradable polyion complex-coated polymeric micelles as drug carriers

点击翻译按钮获取中文摘要

We prepared biodegradable polymeric micelles coated with polyanionic hyaluronic acid (HA) by polyion complex (PIC) formation from positively charged polymeric micelles consisting of amphiphilic biodegradable AB-type diblock copolymers of poly(L-lysine) and poly(L-lactide). The obtained HA-coated micelles showed extremely higher stability under diluted condition and in the presence of serum. Moreover, the HA-coated micelles specifically bound to liver sinusoidal endothelial cells. We also prepared biodegradable polymeric micelles coated with galactose bearing hyaluronic acid (Gal-HA) and investigated cell-specific recognition of the obtained Gal-HA-coated micelles. The obtained results suggested that the Gal-HA-coated micelles showed cell-specific uptake into hepatoma via galactose receptor mediated mechanism.