Role of perlecan in muscle hypertrophy induced by mechanical-stress

基底膜蛋白聚糖在机械应力诱导的肌肉肥大中的作用

• 批准号: 22300223
• 负责人: HIRASAWA Eri
• 金额: $ 11.73万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300223/
• 关键词: メカニカルストレス; サルコペニア; ミオスタチ; パールカン; 筋肥大; ミオスタチン

The aim of this study is to identify the role of perlecan, a multifunctional glycoprotein, in skeletal muscle hypertrophy induced by mechanical stress such as exercise training. We found that in perlecan deficient mice, skeletal muscle hypertrophy was promoted with increased growth factor and myostatin signaling under the mechanical stress. Our findings reveal the important regulatory role of perlecan in muscle hypertrophy induced by mechanical stress.

本研究的目的是确定串珠素，一种多功能糖蛋白，在机械应力，如运动训练引起的骨骼肌肥大的作用。我们发现在串珠素缺陷小鼠中，在机械应力下，骨骼肌肥大随着生长因子和肌生长抑制素信号的增加而促进。我们的研究结果揭示了串珠素在机械应力诱导的肌肉肥大中的重要调节作用。

项目成果

Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation.

• DOI: 10.1016/j.matbio.2012.02.006
• 发表时间: 2012-05
• 期刊: MATRIX BIOLOGY
• 影响因子: 6.9
• 作者: Ishijima, Muneaki;Suzuki, Nobuharu;Hozumi, Kentaro;Matsunobu, Tomoya;Kosaki, Keisuke;Kaneko, Haruka;Hassell, John R.;Arikawa-Hirasawa, Eri;Yamada, Yoshihiko
• 通讯作者: Yamada, Yoshihiko

Synovial perlecan is required for osteophyte formation in knee osteoarthritis.

• DOI: 10.1016/j.matbio.2013.01.004
• 发表时间: 2013-04-24
• 期刊: MATRIX BIOLOGY
• 影响因子: 6.9
• 作者: Kaneko, Haruka;Ishijima, Muneaki;Futami, Ippei;Tomikawa-Ichikawa, Naoki;Kosaki, Keisuke;Sadatsuki, Ryo;Yamada, Yoshihiko;Kurosawa, Hisashi;Kaneko, Kazuo;Arikawa-Hirasawa, Eri
• 通讯作者: Arikawa-Hirasawa, Eri

Heat stress activates the Akt/mTOR signaling pathway in rat skeletal muscle

热应激激活大鼠骨骼肌中的 Akt/mTOR 信号通路

• 发表时间: 2013
• 期刊: Acta Physiol
• 影响因子: 6.3
• 作者: Yoshihara T;Naito H;Kakigi R;Ichinoseki-Sekine N;Ogura Y;Sugiura T;Katamoto S
• 通讯作者: Katamoto S

Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia.

HSPG2 基因与抗精神病药引起的迟发性运动障碍的关联。

• DOI: 10.1038/npp.2009.220
• 发表时间: 2010
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Syu,Aoi;Ishiguro,Hiroki;Inada,Toshiya;Horiuchi,Yasue;Tanaka,Syunsuke;Ishikawa,Maya;Arai,Makoto;Itokawa,Masanari;Niizato,Kazuhiro;Iritani,Shuji;Ozaki,Norio;Takahashi,Makoto;Kakita,Akiyoshi;Takahashi,Hitoshi;Nawa,Hiroyuki;Keino
• 通讯作者: Keino

Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition.

基底膜蛋白缺乏会导致肌肉肥大、肌生长抑制素表达减少以及肌纤维组成发生变化。

• DOI: 10.1016/j.matbio.2010.06.001
• 发表时间: 2010
• 期刊: Matrix biology : journal of the International Society for Matrix Biology
• 作者: Xu,Zhuo;Ichikawa,Naoki;Kosaki,Keisuke;Yamada,Yoshihiko;Sasaki,Takako;Sakai,LynnY;Kurosawa,Hisashi;Hattori,Nobutaka;Arikawa-Hirasawa,Eri
• 通讯作者: Arikawa-Hirasawa,Eri