Creation of small molecular resources with high function based on comprehensive natural products chemistry

在本研究中，我们从多种自然资源的提取物以及本课题组构建的合成化合物文库中，针对主要与癌症疾病相关的TRAIL、Wnt、Hedgehog信号通路进行了筛选研究。因此，我们已经分离出一些对这些信号通路有影响的生物活性天然产物，并在本研究中对这些活性化合物的分子机制进行了研究。

In this study, we performed screening studies targeting TRAIL, Wnt, and Hedgehog signaling pathways which are related to mainly cancer diseases from the extracts of various natural resources as well as synthetic compounds library constructed in our group. As a result, we have isolated a number of bioactive natural products having effects on these signaling pathways and the molecular mechanisms of these active compounds were also investigated in this study.