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Magnetic Beads Amplification based Biosensing System

Magnetic Beads Amplification based Biosensing System
基于磁珠扩增的生物传感系统
批准号:
22360139
负责人:
SANDHU ADARSH
金额:
$11.73万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
翻译
检测用作“磁性标签”的小浓度的小于200 nm尺寸的SPB(超顺磁珠)对于快速、高灵敏度和便携式护理点治疗(POCT)至关重要。目前,磁阻(MR)生物传感器用于检测大浓度的SPB,但是由于这些电子设备的固有噪声,这种方法不适合于监测少量的亚200nm SPB。为了克服传统MR传感器的这种局限性,本研究已经导致了一个简单的程序的开发,用于检测小浓度的子200 nm直径的SPBs的生物传感,通过利用磁诱导自组装的微米尺寸的SPBs到纳米目标。这种方法能够在光学显微镜下监测纳米磁珠对微米尺寸SPB的磁诱导自组装的捕获,以及使用霍尔生物传感器对来自原本不可检测的纳米SPB目标的信号的物理放大,而不使用交流磁场或锁定检测的应用,从而能够产生用于广泛应用的简单POCT协议。
英文摘要
Detection of small concentrations of sub-200 nm sized SPBs (superparamagnetic beads) that are used as ‘magnetic labels’ is critical for rapid, highly sensitive, and portable point of care treatment (POCT). Currently, magnetoresistive (MR) biosensors are used for the detection of large concentrations of SPBs but such an approach is not suitable for monitoring small numbers of sub-200nm SPBs due to the intrinsic noise of these electronic devices. In order to overcome this limitation of conventional MR sensors, this research has led to the development of a straightforward procedure for detecting small concentrations of sub-200-nm-diameter SPBs for biosensing by exploiting magnetically induced self-assembly of micrometer sized SPBs onto nanometer targets. This approach enables the monitoring the capture of magnetically induced self-assembly of micrometer sized SPBs by nanometer magnetic beads under an optical microscope, and the physical amplification of the signal from otherwise undetectable nano-SPB targets using Hall biosensors without using the application of ac magnetic fields or lock-in detection, thereby enabling the production of a simple POCT protocol for a wide range of applications.
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会议论文
Adarsh Sandhu Detection of Magnetic Nanoparticles by Magnetically Mediated Self-Assembly of Superparamagnetic Microbeads for Biosensing
Adarsh Sandhu 通过用于生物传感的超顺磁性微珠的磁介导自组装来检测磁性纳米粒子
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [森本義謙, 阿部正紀, 半田宏]
通讯作者: 半田宏
Planar Microfluidic System based on Electrophoresis for Detection of 130-nm Magnetic Labels for Biosensing
基于电泳的平面微流体系统,用于检测生物传感中的 130 nm 磁性标记
DOI: --
发表时间: 2011
期刊: Japanese Journal of Applied Physics (JJAP)
影响因子: --
作者: [Naohiro Horiuchi, Takuya Hoshina, Hiroaki Takeda, Takaaki Tsurumi, Hayato Sano, 堀内尚紘, 佐野勇人, Naohiro Horiuchi, Hayato Sano, Naohiro Horiuchi, 佐野勇人, Hayato Sano, Naohiro Horiuchi, Hayato Sano, Tomoko Matsumoto, Tomoko Matsumoto, 村松綾, 村松綾, 村松綾, 村松綾, 村松綾, 村松綾, Yoshitaka Morimoto, Tsukasa Takamura]
通讯作者: Tsukasa Takamura
DOI: --
发表时间: 2010
期刊: Japanese Journal of Applied Physics
影响因子: 1.5
作者: [Y. Morimoto,T. Takamura, S. Y. Park, S. Sakamoto, S. Kawata, H. Handa, and A Sandhu]
通讯作者: and A Sandhu
Novel Protocol for Magnetically-Labeled Biosensing Platform
磁标记生物传感平台的新方案
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [A. Takeda, T. Aihara, M. Fukuhare. Y. Ishii. and M. Fukuda, Yoshitaka Morimoto and Adarsh Sandhu]
通讯作者: Yoshitaka Morimoto and Adarsh Sandhu
共 20 条
    極高温用GaN/AlGaNヘテロ構造ホール素子の作製と応用
    • 批准号:
      17656107
    • 项目类别:
      Grant-in-Aid for Exploratory Research
    • 资助金额:
      $2.11万
    • 财政年份:
      2005
    • 负责人:
      SANDHU ADARSH
    • 依托单位:
    海外基金