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Elucidation of nuclear export machinery of tRNA by crystal structural analysis of exportin/tRNA complex

Elucidation of nuclear export machinery of tRNA by crystal structural analysis of exportin/tRNA complex
通过输出蛋白/tRNA 复合物的晶体结构分析阐明 tRNA 的核输出机制
批准号:
22370041
负责人:
YAMASHITA Eiki
金额:
$11.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
In eukaryotic cells, the nucleus, where transcription occurs, and thecytoplasm, where translation takes place, are separated by the nuclear envelope. Theregulation of nucleo-cytoplasmic transport of proteins and RNAs is essential for biologicalactivity. Here, we solve crystal structures of a nuclear export factor and export factorcomplex for non-coding RNA export from the nucleus and the crystal structures reveal RNArecognition mechanism of the nuclear export factor transporting various non cordingRNAs.
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DOI: 10.1093/jb/mvs085
发表时间: 2012-11
期刊: Journal of biochemistry
影响因子: 2.7
作者: [K. Takeshita;T. Tezuka;Y. Isozaki;E. Yamashita;Mamoru Suzuki;Minsoo Kim;Y. Yamanashi;Tadashi Yamamoto-Tad]
通讯作者: K. Takeshita;T. Tezuka;Y. Isozaki;E. Yamashita;Mamoru Suzuki;Minsoo Kim;Y. Yamanashi;Tadashi Yamamoto-Tad
DOI: 10.1073/pnas.1019629108
发表时间: 2011-05-31
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子: 11.1
作者: [Takeshita, Kohei, Suetake, Isao, Tajima, Shoji]
通讯作者: Tajima, Shoji
Cramer W. A., Quinone-dependent proton transfer pathways in the photosynthetic cytochrome b6f complex.
Cramer W.A.,光合细胞色素 b6f 复合物中醌依赖性质子转移途径。
DOI: --
发表时间: 2013
期刊: Proc Natl Acad Sci USA
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作者: [Miya, M., Satoh, T.P., Sado, T. & Nishida, M., HasanS.S.,YamashitaE.,BaniulisD.,CramerW.A.]
通讯作者: HasanS.S.,YamashitaE.,BaniulisD.,CramerW.A.
Crystallization and preliminary X-ray crystallographic study of the human MST2 SARAH domain.
人类 MST2 SARAH 结构域的结晶和初步 X 射线晶体学研究。
DOI: --
发表时间: 2011
期刊: Acta Cryst.
影响因子: --
作者: [Hirose T, Maita N, Taniguchi H, Sharpless KB, Omura S, Sunazuka T, ZakharovS.D.,SharmaO.,ZhalninaM.V.,YamashitaE.,CramerW.A., 宮 正樹・西田 睦, Takesita K, SongJ.,HongH.,ChoiS.,LeeY.H.,YamashitaE.,BaeS.C.,ParkI.Y.,LeeS.J.]
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