Studies on molecular mechanisms for functional evolution of bacteria in the environment

为深入了解环境中细菌的功能演化，对降解人工合成氯代农药γ-HCH的细菌和降解氯代化合物的关键酶脱卤酶进行了详细分析。(1)（2）根据γ-HCH降解菌基因组的结构和功能以及移动的遗传元件，提出了γ-HCH降解菌的出现和进化过程;（3）建立了环境中细菌进化过程的验证系统。

To get insights into the functional evolution of bacteria in the environment, bacteria, which degrade man-made chlorinated pesticide γ-HCH, and dehalogenases, which are key enzymes for the degradation of chlorinated compounds, were analyzed in detail. (1) structure-function relationships of some dehalogenases were revealed and their evolution process was suggested, (2) the process of appearance and evolution of γ-HCH-degrading bacteria was proposed on the basis of the structure and function of their genomes and mobile genetic elements, and (3) the system for verifying evolution process of bacteria in the environment was constructed.