Studies on molecular mechanisms for functional evolution of bacteria in the environment

为了深入了解环境中细菌的功能进化，对降解人造氯化农药γ-HCH的细菌和降解氯化化合物的关键酶脱卤酶进行了详细的分析。(1)揭示了一些脱卤酶的结构-功能关系，并提出了它们的进化过程；(2)根据γ- hch降解菌基因组的结构和功能以及可移动遗传元件的结构和功能，提出了γ- hch降解菌的外观和进化过程；(3)构建了细菌在环境中的进化过程验证系统。

To get insights into the functional evolution of bacteria in the environment, bacteria, which degrade man-made chlorinated pesticide γ-HCH, and dehalogenases, which are key enzymes for the degradation of chlorinated compounds, were analyzed in detail. (1) structure-function relationships of some dehalogenases were revealed and their evolution process was suggested, (2) the process of appearance and evolution of γ-HCH-degrading bacteria was proposed on the basis of the structure and function of their genomes and mobile genetic elements, and (3) the system for verifying evolution process of bacteria in the environment was constructed.