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Generation of transgenic mice expressing soluble forms of Siglecs as a model for influenza-resistant pigs

Generation of transgenic mice expressing soluble forms of Siglecs as a model for influenza-resistant pigs
表达可溶形式 Siglecs 的转基因小鼠的产生作为抗流感猪的模型
批准号:
22380161
负责人:
ONO Etsuro
金额:
$13.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
To confer the antiviral potential against influenza virus to pigs as a mixing vessel for creating a “new” influenza virus, we investigated the ability of Siglecs to inhibit influenza virus infection in vitro and in vivo by using Madin-Derby canine kidney (MDCK) cells and transgenic mice expressing a soluble form of human Siglec molecules. The transformed MDCK cells showed a significant resistance, but not the transgenic mice
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Possible antiviral potential of soluble forms of Siglecs in influenza virus infection
可溶形式的 Siglecs 在流感病毒感染中可能具有抗病毒潜力
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Tatsufumi Usui, Kinuyo Ozaki, Hiroki Takakuwa, Hiroichi Ozaki, Hiroshi Ito, Toshiyuki Murase, Koichi Otsuki, Toshihiro Ito, Tsuyoshi Yamaguchi and Etsuro Ono]
通讯作者: Tsuyoshi Yamaguchi and Etsuro Ono
Possible antiviral potential of soluble forms of Siglecs in influenza virusinfection
可溶形式的 Siglecs 在流感病毒感染中可能具有抗病毒潜力
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Tatsufumi Usui, Kinuyo Ozaki, Hiroki Takakuwa, Hiroichi Ozaki, Hiroshi Ito, Toshiyuki Murase, Koichi Otsuki, Toshihiro Ito, Tsuyoshi Yamaguchi, Etsuro Ono]
通讯作者: Etsuro Ono
Antiviral effects of anti-PB2 monoclonal intrabody inhibiting the viral RNA transcription on influenza virus infections
抗PB2单克隆体内抑制病毒RNA转录对流感病毒感染的抗病毒作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yoshikazu Fujimoto, Kinuyo Ozaki, Hiroki Takakuwa, Hiroshi Ito, Tatsufumi Usui, Hiroichi Ozaki, Toshiyuki Murase, Tsuyoshi Yamaguchi, Koichi Otsuki, Toshihiro Ito, Hiroshi Kida and Etsuro Ono]
通讯作者: Hiroshi Kida and Etsuro Ono
Generation of transboundary animal diseases-resistant animals by genetic modification technologies to Rab-GTPases genes
  • 批准号:
    20K20577
  • 项目类别:
    Grant-in-Aid for Challenging Research (Pioneering)
  • 资助金额:
    $16.56万
  • 财政年份:
    2020
  • 负责人:
    ONO Etsuro
  • 依托单位:
GENERATION OF TRANSGENIC MICE EXPRESSING SOLUBLE FORM OF PORCINE NECTIN-1 AS A MODEL FOR PSEUDORABIES-RESISTANT LIVE STOCK
  • 批准号:
    17580265
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.24万
  • 财政年份:
    2005
  • 负责人:
    ONO Etsuro
  • 依托单位:
Generation of Pseudorabies-resistant Animals by Germ-line Transformation
  • 批准号:
    12556048
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $7.3万
  • 财政年份:
    2000
  • 负责人:
    ONO Etsuro
  • 依托单位:
Neuropathogenic abnormalities in transgenic mice expressing transcription factors of neurotropic viruses in the central nervous system
  • 批准号:
    11660291
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.43万
  • 财政年份:
    1999
  • 负责人:
    ONO Etsuro
  • 依托单位:
海外基金