Generation of transgenic mice expressing soluble forms of Siglecs as a model for influenza-resistant pigs
Generation of transgenic mice expressing soluble forms of Siglecs as a model for influenza-resistant pigs
批准号:
22380161
负责人:
ONO Etsuro
金额:
$13.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
To confer the antiviral potential against influenza virus to pigs as a mixing vessel for creating a “new” influenza virus, we investigated the ability of Siglecs to inhibit influenza virus infection in vitro and in vivo by using Madin-Derby canine kidney (MDCK) cells and transgenic mice expressing a soluble form of human Siglec molecules. The transformed MDCK cells showed a significant resistance, but not the transgenic mice
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会议论文
Possible antiviral potential of soluble forms of Siglecs in influenza virus infection
可溶形式的 Siglecs 在流感病毒感染中可能具有抗病毒潜力
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tatsufumi Usui, Kinuyo Ozaki, Hiroki Takakuwa, Hiroichi Ozaki, Hiroshi Ito, Toshiyuki Murase, Koichi Otsuki, Toshihiro Ito, Tsuyoshi Yamaguchi and Etsuro Ono]
通讯作者:
Tsuyoshi Yamaguchi and Etsuro Ono
Possible antiviral potential of soluble forms of Siglecs in influenza virusinfection
可溶形式的 Siglecs 在流感病毒感染中可能具有抗病毒潜力
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tatsufumi Usui, Kinuyo Ozaki, Hiroki Takakuwa, Hiroichi Ozaki, Hiroshi Ito, Toshiyuki Murase, Koichi Otsuki, Toshihiro Ito, Tsuyoshi Yamaguchi, Etsuro Ono]
通讯作者:
Etsuro Ono
Antiviral effects of anti-PB2 monoclonal intrabody inhibiting the viral RNA transcription on influenza virus infections
抗PB2单克隆体内抑制病毒RNA转录对流感病毒感染的抗病毒作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yoshikazu Fujimoto, Kinuyo Ozaki, Hiroki Takakuwa, Hiroshi Ito, Tatsufumi Usui, Hiroichi Ozaki, Toshiyuki Murase, Tsuyoshi Yamaguchi, Koichi Otsuki, Toshihiro Ito, Hiroshi Kida and Etsuro Ono]
通讯作者:
Hiroshi Kida and Etsuro Ono
Generation of transboundary animal diseases-resistant animals by genetic modification technologies to Rab-GTPases genes
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批准号:20K20577
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项目类别:Grant-in-Aid for Challenging Research (Pioneering)
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资助金额:$16.56万
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财政年份:2020
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负责人:ONO Etsuro
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依托单位:
GENERATION OF TRANSGENIC MICE EXPRESSING SOLUBLE FORM OF PORCINE NECTIN-1 AS A MODEL FOR PSEUDORABIES-RESISTANT LIVE STOCK
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批准号:17580265
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:ONO Etsuro
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依托单位:
Generation of Pseudorabies-resistant Animals by Germ-line Transformation
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批准号:12556048
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.3万
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财政年份:2000
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负责人:ONO Etsuro
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依托单位:
Neuropathogenic abnormalities in transgenic mice expressing transcription factors of neurotropic viruses in the central nervous system
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批准号:11660291
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1999
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负责人:ONO Etsuro
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依托单位:
Intracellular immunization against Aujeszky's disease
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批准号:04660312
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1992
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负责人:ONO Etsuro
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依托单位:
海外基金