The spinal defecation center-mediated prokinetic effect of ghrelin and its involvement in dysmotility of the large intestine.

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The aim of this work was to clarify the regulatory mechanism of the central nervous system on gut motility. By using in vivo experimental system in which gut motility can be assessed in the presence of intact neural connection between the central nervous system and gut, it has been demonstrated that ghrelin and dopamine injected into the spinal defecation center elicit large propulsive colorectral motility. In addition, neurons sensitive to ghrelin and dopamine have been identified in the spinal cord. These findings would provide a novel therapeutic strategy for stress-induced diarrhea and constipation.