Induction of hibernation in the rat, a non-hibernator, and its application to therapy for ischemic injury.

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An extreme hypothermic condition would be beneficial for developing new therapies, especially for cancers or reperfusion injury in ischemic diseases. The present study was designed to develop a method for inducing hypothermia, which is equivalent to hibernating animals, in non-hibernators. In rats(non-hibernator), hypothermia forcibly induced by inhalation anesthesia combined with cooling of the animals resulted in cardiac arrest when their body temperatures were dropped around 25℃. In contrast, body temperature of rats can be reduced less than 10℃ when inhalation of the anesthesia was stopped during the cooling process.