Studies on isolation, total synthesis and medicinal chemistryof natural products with regulating activities on memory and pain.

为了开发新的癌症疼痛镇痛药，对具有corynanthe型骨架的先导化合物进行了结构修饰，从而产生了具有强镇痛活性和抗微粒体代谢稳定性的新衍生物。iboga型吲哚生物碱是一类新的CB1受体拮抗剂。以不对称方式合成了一种具有伊博加结构的新型生物碱。为了研究开发痴呆症药物的种子分子，对石蒜生物碱进行了分离、结构解析和全合成。

To develop new analgesics for cancer pain, structure of the lead-compound having Corynanthe-type skeleton was modified, resulting in the creation of new derivatives with potent analgesic activity as well as with stability against microsomal metabolism. Iboga-type indole alkaloids were found to be a new class of antagonist of CB1 receptors. Voacangalactonine, a new alkaloid possessing Iboga structure, was synthesized in an asymmetric manner. To investigate the seeds molecules for development of medicines for dementia, isolation, structure elucidation, and total syntheses of Lycopodium alkaloids were performed.