Studies on isolation, total synthesis and medicinal chemistryof natural products with regulating activities on memory and pain.

为了开发用于癌症疼痛的新镇痛剂，对具有Corynanthe型骨架的先导化合物的结构进行了修饰，从而产生了具有有效镇痛活性以及对微粒体代谢稳定的新衍生物。Iboga型吲哚生物碱是一类新的CB1受体拮抗剂。以不对称方法合成了具有Iboga结构的新生物碱Voacangalactonine。为了研究用于开发痴呆症药物的种子分子，对石松属生物碱进行了分离、结构解析和全合成。

To develop new analgesics for cancer pain, structure of the lead-compound having Corynanthe-type skeleton was modified, resulting in the creation of new derivatives with potent analgesic activity as well as with stability against microsomal metabolism. Iboga-type indole alkaloids were found to be a new class of antagonist of CB1 receptors. Voacangalactonine, a new alkaloid possessing Iboga structure, was synthesized in an asymmetric manner. To investigate the seeds molecules for development of medicines for dementia, isolation, structure elucidation, and total syntheses of Lycopodium alkaloids were performed.