Search, asymmetric synthesis, and medicinal chemistry study on the plant alkaloids that regulate the brain nervous system.

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In order to find new biologically active compounds that act on the brain nervous systems, we have investigated plant alkaloids. As a result, several new alkaloids having opioid agonistic activity or acetylcholine-esterase inhibitory activity were found. Their asymmetric total syntheses were also achieved. Further, based on those natural products, we have developed potent channel blocker on NMDA receptors, which would be a seed molecule for dementia medicine, as well as novel and quite potent opioid agonist, which would be a lead compound for new analgesic.