Mechanism underlying the regulation of brain function through sphingosine kinase/S1P signaling

点击翻译按钮获取中文摘要

Electrophysiological studies demonstrated that S1P signaling causes glutamate release from mossy fiber teminals in the hippocampus as well as it doesfrom hippocampal neurons, suggesting that this signaling system may regulate memory formation and learning in the brain. Immunohistochemical analysis revealed that sphingosine kinase 1 is rich in cerebellum and substantia nigra as well as mossy fibers in the hippocampussuggesting the signaling system may work in GABAnergic and dopaminergic neurons as well.Further studies are necessary to elucidate the function of S1P in the brain.