Pathogenetical and etiological study on biliary diseases with respect to embryological close relation and cellular similarities to pancreas

胆道疾病与胰腺胚胎学密切关系和细胞相似性的病理遗传学和病因学研究

• 批准号: 22390067
• 负责人: NAKANUMA Yasuni
• 金额: $ 11.23万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390067/
• 关键词: 付属腺; 胆道腫瘍; 膵腫瘍; 膵外分泌腺; 胆道; Hes1; Pdx1

Biliary tract and pancreas derive from endoderm foregut almost same time, and both show similar tissue and cellular structures and phenotypes. With respect to these similarities, the etiology and pathogenesis of biliary tract diseases were examined. The data obtained in this study were summarized as follows. I)Some of inflammatory diseases of the biliary tract and pancreas such as IgG4-related scloerosing disease and alcoholic pancreatitis and biliary disease were frequently overlapped and showed similar pathological features. II)Pancreatic duct adenocarcinoma and biliary tract carcinoma including their pre-neoplastic lesions showed similar pathological and phenotypic features. III) Intraductal papillary tumor of the pancreas and biliary tract also showed similar features and phenotypes. In conclusion, the data obtained in this study based on the similarities between pancreas and biliary tract were applicable in the therapeutical approaches of the biliary tract diseases.

胆道和胰腺几乎同时起源于内胚层前肠，两者具有相似的组织和细胞结构及表型。根据这些相似性，对胆道疾病的病因和发病机制进行了研究。本研究中获得的数据总结如下。I）一些胆道和胰腺的炎性疾病，如IgG 4相关的硬化性疾病和酒精性胰腺炎和胆道疾病经常重叠，并显示出相似的病理特征。胰管腺癌和胆道癌包括其癌前病变显示相似的病理和表型特征。胰腺和胆道的导管内乳头状肿瘤也表现出相似的特征和表型。总之，本研究中基于胰腺和胆道之间的相似性获得的数据适用于胆道疾病的治疗方法。

项目成果

Spread of hilar cholangiocarcinomas via peribiliary gland network: a hither-to-unrecognized route of periductal infiltration

肝门部胆管癌通过胆管周围腺网络扩散：迄今为止尚未认识的导管周围浸润途径

• 发表时间: 2013
• 期刊: Int J Clin Exp Pathol
• 作者: Sato H;Nakanuma Y;Kozaka K;Sato Y;Ikeda H.
• 通讯作者: Ikeda H.

Intraductal papillary neoplasm of the bile dict in liver cirrhosis with hepatocellular carcinoma

肝硬化合并肝细胞癌胆管内乳头状肿瘤

• 发表时间: 2011
• 期刊: World J Gastroenterol
• 作者: Nakanuma Y;et al
• 通讯作者: et al

肝内胆管、胆道、膵の腫瘍分類:WHOの新たな試みを含めて、病理・発癌の観点から

肝内胆管、胆道和胰腺的肿瘤分类：从病理学和癌变的角度，包括WHO的新尝试

• 发表时间: 2011
• 期刊: 肝胆膵
• 作者: Takako Nakano-Yokomizo;et.al.;中沼 安二
• 通讯作者: 中沼 安二

Biliary tract carcinoma and pancreatic duct adenocarcinoma show sililar phenotypes and behaviors suggestion of similar background and development.

胆道癌和胰管腺癌表现出相似的表型和行为，提示相似的背景和发展。

• 发表时间: 2013
• 作者: Chatani E;et al.;戸塚直也;Yamakawa K.;Nakanuma Y
• 通讯作者: Nakanuma Y

Biliary tract carcinoma and pancreatic duct adenocarcinoma show similar phenotypes and behaviors suggestion of similar background and development

胆道癌和胰管腺癌表现出相似的表型和行为，提示相似的背景和发展

• 发表时间: 2013
• 作者: Hideto Watanabe;Hiroyasu Ogawa;Masafumi Shionyu;Nobui Sugiura;Sonoko Hatano;Naoko Nagai;Takashi Sato Hisashi Narimatsu;Katsuji Shimizu;Koji Kimata;Chigusa Nakhashi-Oda C;Ding Y;Nakanuma Y
• 通讯作者: Nakanuma Y