Proposal of intraductal papillary neoplasm of the bile duct and molecular pathological study on its development and progression

胆管内乳头状肿瘤的提出及其发生、发展的分子病理学研究

• 批准号: 19390098
• 负责人: NAKANUMA Yasuni
• 金额: $ 9.98万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390098/
• 关键词: 胆管系; 膵腫瘍; 管腔内乳頭状腫瘍; 胆管癌; 上皮内腫瘍; 乳頭状腫瘍; 粘液癌; 通常型胆管癌; 癌; 遺伝子; 臨床; 病理学; 細胞・組織; 胆管上皮; 粘液産生; 表現型; 膵管腫瘍; 襄胞腫瘍; 浸潤; 嚢胞腫瘍

The followings are the main results and contributions. Intraductal papillary neoplasm of bile duct (IPNB) shares many features of intraductal papillary mucinous neoplasm of pancreas, particularly main duct type, such as gross and imaging features and histologies. IPNB are classified into the pancreatobiliary type, intestinal type, gastric type and oncocytic type, and these four types show characteric features. During the development and progression of IPNB, p53 and p16 are significantly involved, and MMP7 plays an important role in the progression of IPNB. These issues on IPNB have been discussed in several meetings in Japan and also USA, and IPNB has been accepted as a disease entity in biliary tract tumors. Furthermore, IPNB has just introduced as a disease entity and preneoplastic lesion of cholangiocarcinoma in WHO blue book on Gastrointestinal tract tumor, 2010, and this topic is now discussed and studies worldwide.

以下是主要的结果和贡献。胆管导管内乳头状肿瘤（IPNB）具有胰腺导管内乳头状粘液瘤的许多特征，特别是主导管类型，如大体、影像学特征和组织学。IPNB分为胰胆管型、肠型、胃型和嗜瘤细胞型，这四种类型都有各自的特点。在IPNB的发生发展过程中，p53和p16显著参与，MMP7在IPNB的发展过程中发挥重要作用。这些关于IPNB的问题已经在日本和美国的几次会议上进行了讨论，IPNB已被接受为胆道肿瘤的疾病实体。此外，IPNB作为胆管癌的一种疾病实体和瘤前病变刚刚被WHO 2010年《胃肠道肿瘤蓝皮书》引入，目前正在世界范围内进行讨论和研究。

项目成果

慢性胆管上皮障害からみた肝内胆管癌のハイリスク因子-肝内胆管癌2008,up-to-date

从慢性胆管上皮疾病的角度探讨肝内胆管癌的高危因素 - Intrahepatic cholangiocarcinoma 2008, up-to-date

• 发表时间: 2008
• 期刊: 肝胆膵 57(1)
• 作者: 中沼安二;ほか3名
• 通讯作者: ほか3名

Express of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts.

基质金属蛋白酶7的表达是肝门周围胆管癌、肝门胆管癌和肝外胆管癌术后不良预后因素。

• 发表时间: 2008
• 期刊: Hum Pathol. 39
• 作者: Itatsu K;Zen Y;Yamaguchi J;Ohira S;Ishikawa A;IKeda H;Sato Y;Harada K;Sasaki M;Sasaki M;Sakamoto H;Nagino M;Nimufa Y;Ohta T;Nakanuma Y.
• 通讯作者: Nakanuma Y.

肝内胆管の解剖と病理

肝内胆管的解剖和病理学

• 发表时间: 2010
• 作者: 仙谷和弘;安井 弥;中沼安二
• 通讯作者: 中沼安二

肝内結石症からの発癌過程におけるHSP27の発現と腫瘍マーカーとしての意義

HSP27在肝内胆管结石癌变过程中的表达及其肿瘤标志物意义

• 发表时间: 2009
• 作者: 佐藤保則;中沼安二
• 通讯作者: 中沼安二

Extrahepatic bile duct carcinoma with extensive intraepithelial spread: a clinicopathological study of 21 cases

• DOI: 10.1038/modpathol.2008.65
• 发表时间: 2008-07-01
• 期刊: MODERN PATHOLOGY
• 影响因子: 7.5
• 作者: Nakanishi, Yoshitsugu;Zen, Yoh;Kondo, Satoshi
• 通讯作者: Kondo, Satoshi