Regulation of environmental responses and its physiological significance in Vibrio species

我们已经确定了霍乱弧菌的两个氨基酸受体趋化，其中一个也感应牛磺酸，胆汁的主要成分。牛磺酸反应和牛磺酸化学受体的表达在高温下增强，提出了牛磺酸趋向性在细菌发病机制中发挥作用的有趣可能性。我们还在海洋弧菌中发现了一个氨基酸化感受器，其表达可能与侧鞭毛协同诱导。我们还发现趋化相关的信号蛋白在微有氧条件下定位于细胞极点，这意味着这些信号系统在特定条件下发挥作用，如在宿主肠道中。

We have identified two amino acid receptors of Vibrio cholerae for chemotaxis, one of which also senses taurine, a major component of bile. The taurine response and the expression of the taurine chemoreceptor was enhanced at elevated temperature, raising an intriguing possibility that taurine taxis play a role in pathogenesis of the bacteria. We also identified an amino acid chemoreceptor in marine Vibrio sp., the expression of which may be induced coordinately with lateral flagella. We also found that chemotaxis-related signaling proteins localized to a cell pole under micro aerobic conditions, implying that these signaling systems function under specific conditions such as in the host intestine.