Regulation of environmental responses and its physiological significance in Vibrio species

我们已经确定了两个氨基酸受体的霍乱弧菌的趋化性，其中之一也感觉牛磺酸，胆汁的主要成分。牛磺酸反应和牛磺酸化学受体的表达在升高的温度下增强，提出了一个有趣的可能性，牛磺酸的趋化性发挥作用的致病细菌。我们还在海洋弧菌中鉴定了一种氨基酸化学感受器，其表达可与侧鞭毛协同诱导。我们还发现趋化性相关的信号蛋白定位于微需氧条件下的细胞极，这意味着这些信号系统的功能在特定的条件下，如在宿主肠道。

We have identified two amino acid receptors of Vibrio cholerae for chemotaxis, one of which also senses taurine, a major component of bile. The taurine response and the expression of the taurine chemoreceptor was enhanced at elevated temperature, raising an intriguing possibility that taurine taxis play a role in pathogenesis of the bacteria. We also identified an amino acid chemoreceptor in marine Vibrio sp., the expression of which may be induced coordinately with lateral flagella. We also found that chemotaxis-related signaling proteins localized to a cell pole under micro aerobic conditions, implying that these signaling systems function under specific conditions such as in the host intestine.