Biomarker searches and clinical applications of gastrointestinal and hepatobiliary cancers by multidisciplinary approaches
Biomarker searches and clinical applications of gastrointestinal and hepatobiliary cancers by multidisciplinary approaches
批准号:
22390114
负责人:
NOMURA Fumio
金额:
$11.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
通过血清深层蛋白质组分析确定了过量饮酒的新生物标志物。除了表达蛋白质组学,我们还探索了针对癌组织中过表达蛋白的抗体。血清抗ku86被认为是肝细胞癌的潜在早期诊断指标。牙龈沟液(GCF)作为近端液体的典型样本进行分析,以寻找牙周病的生物标志物。
英文摘要
Novel biomarker for excessive drinking was determined by serum deep proteome analyses. In addition to expression proteomics, antibody against proteins overexpressed in cancer tissues were explored. Serum anti-Ku86 was found to be a potential early diagnostic marker for hepatocellular carcinoma. Gingival crevicular fluid (GCF) was analyzed as a typical example of proximal fluids to search for biomarkers of periodontal diseases.
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DOI:
10.1155/2012/623190
发表时间:
2012
期刊:
International journal of proteomics
影响因子:
--
作者:
[Kimura A, Sogawa K, Satoh M, Kodera Y, Yokosuka O, Tomonaga T, Nomura F]
通讯作者:
Nomura F
歯肉溝滲出液のプロテオーム解析による歯周疾患マーカーの探索
通过龈沟液蛋白质组分析寻找牙周病标志物
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[土田祥央, 佐藤守, 曽川一幸, 川島祐介, 荷堂清香, 澤井摂, 西村基, 小寺義男, 松下一之, 野村文夫]
通讯作者:
野村文夫
Comprehensive proteome analysis in search for biomarkers of hepatocellular carcinoma and its high risk group
综合蛋白质组分析寻找肝细胞癌及其高危人群的生物标志物
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tagashira H, Fukunaga K, 野村文夫]
通讯作者:
野村文夫
DOI:
10.1111/j.1530-0277.2012.01883.x
发表时间:
2013
期刊:
Alcoholism, clinical and experimental research
影响因子:
--
作者:
[M. Yamada;M. Satoh;Masanori Seimiya;K. Sogawa;S. Itoga;T. Tomonaga;F. Nomura]
通讯作者:
M. Yamada;M. Satoh;Masanori Seimiya;K. Sogawa;S. Itoga;T. Tomonaga;F. Nomura
DOI:
10.1186/1471-230x-10-140
发表时间:
2010-11-29
期刊:
BMC gastroenterology
影响因子:
2.4
作者:
[Ritchie SA, Heath D, Yamazaki Y, Grimmalt B, Kavianpour A, Krenitsky K, Elshoni H, Takemasa I, Miyake M, Sekimoto M, Monden M, Tomonaga T, Matsubara H, Sogawa K, Matsushita K, Nomura F, Goodenowe DB]
通讯作者:
Goodenowe DB
共 32 条
Multidisciplinary modificomics to search for novel and early markers to detect hepatobiliary cancers
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批准号:25670266
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:NOMURA Fumio
-
依托单位:
Development of early diagnostic markers for gastrointestinal and hepatobiliary cancers by multi-strategic proteome analyses
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批准号:19390154
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.48万
-
财政年份:2007
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负责人:NOMURA Fumio
-
依托单位:
Comprehensive proteome analyses toward biomaker discovery for gastrointestinal and hepatobiliary cancers
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批准号:17590485
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:NOMURA Fumio
-
依托单位:
Searches for novel tumor markers for gastrointestinal cancers by ProteinChip technology
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批准号:13672413
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2001
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负责人:NOMURA Fumio
-
依托单位:
Signal transduction in hepatocytes-Long-term alcohol effects on small G-proteins
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批准号:08670552
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1996
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负责人:NOMURA Fumio
-
依托单位:
Effects of long-term alcohol intake on G Protein mediated callvlar events in hepatocytes
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批准号:06670517
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1994
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负责人:NOMURA Fumio
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依托单位:
In vitro assessment of susceptibility to toxic drug metabolites
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批准号:62570309
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1987
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负责人:NOMURA Fumio
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依托单位:
海外基金