Biomarker searches and clinical applications of gastrointestinal and hepatobiliary cancers by multidisciplinary approaches
Biomarker searches and clinical applications of gastrointestinal and hepatobiliary cancers by multidisciplinary approaches
批准号:
22390114
负责人:
NOMURA Fumio
金额:
$11.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
通过血清深层蛋白质组分析确定了过量饮酒的新生物标志物。除了表达蛋白质组学,我们还探索了针对癌组织中过表达蛋白的抗体。血清抗ku86被认为是肝细胞癌的潜在早期诊断指标。牙龈沟液(GCF)作为近端液体的典型样本进行分析,以寻找牙周病的生物标志物。
英文摘要
Novel biomarker for excessive drinking was determined by serum deep proteome analyses. In addition to expression proteomics, antibody against proteins overexpressed in cancer tissues were explored. Serum anti-Ku86 was found to be a potential early diagnostic marker for hepatocellular carcinoma. Gingival crevicular fluid (GCF) was analyzed as a typical example of proximal fluids to search for biomarkers of periodontal diseases.
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DOI:
10.1155/2012/623190
发表时间:
2012
期刊:
International journal of proteomics
影响因子:
--
作者:
[Kimura A, Sogawa K, Satoh M, Kodera Y, Yokosuka O, Tomonaga T, Nomura F]
通讯作者:
Nomura F
歯肉溝滲出液のプロテオーム解析による歯周疾患マーカーの探索
通过龈沟液蛋白质组分析寻找牙周病标志物
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[土田祥央, 佐藤守, 曽川一幸, 川島祐介, 荷堂清香, 澤井摂, 西村基, 小寺義男, 松下一之, 野村文夫]
通讯作者:
野村文夫
Comprehensive proteome analysis in search for biomarkers of hepatocellular carcinoma and its high risk group
综合蛋白质组分析寻找肝细胞癌及其高危人群的生物标志物
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tagashira H, Fukunaga K, 野村文夫]
通讯作者:
野村文夫
DOI:
10.1111/j.1530-0277.2012.01883.x
发表时间:
2013
期刊:
Alcoholism, clinical and experimental research
影响因子:
--
作者:
[M. Yamada;M. Satoh;Masanori Seimiya;K. Sogawa;S. Itoga;T. Tomonaga;F. Nomura]
通讯作者:
M. Yamada;M. Satoh;Masanori Seimiya;K. Sogawa;S. Itoga;T. Tomonaga;F. Nomura
ジェムシタビン耐性ヒト膵癌細胞株のプロテオーム解析
吉西他滨耐药人胰腺癌细胞系的蛋白质组分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[佐藤守, 高野重紹, 石橋真澄, 吉富秀幸, 西村基, 曽川一幸, 松下一之, 賀川真吾, 荷堂清香, 宮崎勝, 野村文夫]
通讯作者:
野村文夫
共 32 条
Multidisciplinary modificomics to search for novel and early markers to detect hepatobiliary cancers
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批准号:25670266
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:NOMURA Fumio
-
依托单位:
Development of early diagnostic markers for gastrointestinal and hepatobiliary cancers by multi-strategic proteome analyses
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批准号:19390154
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.48万
-
财政年份:2007
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负责人:NOMURA Fumio
-
依托单位:
Comprehensive proteome analyses toward biomaker discovery for gastrointestinal and hepatobiliary cancers
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批准号:17590485
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2005
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负责人:NOMURA Fumio
-
依托单位:
Searches for novel tumor markers for gastrointestinal cancers by ProteinChip technology
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批准号:13672413
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2001
-
负责人:NOMURA Fumio
-
依托单位:
Signal transduction in hepatocytes-Long-term alcohol effects on small G-proteins
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批准号:08670552
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1996
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负责人:NOMURA Fumio
-
依托单位:
Effects of long-term alcohol intake on G Protein mediated callvlar events in hepatocytes
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批准号:06670517
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
-
财政年份:1994
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负责人:NOMURA Fumio
-
依托单位:
In vitro assessment of susceptibility to toxic drug metabolites
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批准号:62570309
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1987
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负责人:NOMURA Fumio
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依托单位:
海外基金