Development of molecular targeted therapy of multiple sclerosis on the basis of membrane protein microarray analysis and gene interactions

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In Japanese demyelinating disease, whereas DRB1*0901 is a disease resi stance gene regardless of the disease phenotype, disease susceptibility gene revealed that depending on the disease phenotype. IL7RA gene, a disease susceptibility gene in Western Caucasian, was shown to be a disease susceptibility gene in Japanese MS. The IL2RA gene, may contribute to disease susceptibility only when it interacts with HLA-DRB1*1501 or HLA-DRB1*0405. By using a cell-free protein synthesis system, LUZP1 is obtained as a self-antigen significantly more in CIDP than Balo disease, SOX6 was obtained as a self-antigen significantly more in MS than Balo disease and CIDP. The high sensitivity anti-AQP4 antibody assay revealed that IgG1 is associated with disease duration, and there was a reverse correlation between the spinal cord lesion length IgG2 .