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Genome-wide analysis of copy number variants in schizophrenia

Genome-wide analysis of copy number variants in schizophrenia
精神分裂症拷贝数变异的全基因组分析
批准号：
22390223
负责人：
OZAKI Norio
金额：
$11.9万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390223/
关键词：
統合失調症ゲノムコピー数多型神経発達CNVコピー数変異

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中文摘要
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英文摘要
We have performed high resolution genome wide copy number (CNV) screening of Japanese schizophrenic patients. Besides the known large CNVs that are previously reported to be associated with schizophrenia, we found novel variations. Smaller CNVs were followed up using lymphoblastoid cell lines (LCL) in order to measure expressional impact. No association between VIPR2duplication and schizophrenia was identified. In conclusion, our study demonstrated that combination of high resolution CNV screening and transcriptomics is useful methodfor investigating genetic susceptibility to schizophrenia.
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会议论文
Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures
DOI： 10.1016/j.schres.2009.12.024
发表时间： 2010-06
期刊： Schizophrenia Research
影响因子： 4.5
作者： [Makoto Takahashi;Hiroshi Hayashi;Yuichiro Watanabe;K. Sawamura;N. Fukui;J. Watanabe;T. Kitajima;Y. Yamanouchi;N. Iwata;K. Mizukami;T. Hori;K. Shimoda;H. Ujike;N. Ozaki;Kentaro Iijima;Kazuo Takemura;H. Aoshima;T. Someya]
通讯作者： Makoto Takahashi;Hiroshi Hayashi;Yuichiro Watanabe;K. Sawamura;N. Fukui;J. Watanabe;T. Kitajima;Y. Yamanouchi;N. Iwata;K. Mizukami;T. Hori;K. Shimoda;H. Ujike;N. Ozaki;Kentaro Iijima;Kazuo Takemura;H. Aoshima;T. Someya
Myelin-related abnormality of schizophrenia: genetic, imaging and postmortem study.
精神分裂症的髓磷脂相关异常：遗传、影像学和尸检研究。
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [Yamamori H, Hashimoto R, Verrall L, Yasuda Y, Ohi K, Fukumoto M, Umeda-Yano S, Ito A, Takeda M, Ozaki N]
通讯作者： Ozaki N
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients.
DOI： 10.1371/journal.pone.0036836
发表时间： 2012
期刊： PloS one
影响因子： 3.7
作者： [Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N]
通讯作者： Ozaki N
Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis
DOI： 10.1002/ajmg.b.32043
发表时间： 2012-06-01
期刊： AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
影响因子： 2.8
作者： [Ohi, Kazutaka, Hashimoto, Ryota, Takeda, Masatoshi]
通讯作者： Takeda, Masatoshi
共 20 条
    Genetic screening of Japanese macaque aiming at discovery of primate models for psychiatric disorders
    • 批准号：
      25670516
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.41万
    • 财政年份：
      2013
    • 负责人：
      OZAKI Norio
    • 依托单位：
      Nagoya University
    Identification of rare genetic variants associated with bipolar disorder and comprehensive analysis to elucidate its pathophysiology
    • 批准号：
      25253072
    • 项目类别：
      Grant-in-Aid for Scientific Research (A)
    • 资助金额：
      $29.12万
    • 财政年份：
      2013
    • 负责人：
      OZAKI Norio
    • 依托单位：
      Nagoya University
    Transcriptome Analysis of Schizophrenia
    • 批准号：
      23659563
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.41万
    • 财政年份：
      2011
    • 负责人：
      OZAKI Norio
    • 依托单位：
      Nagoya University
    Analysis of molecular pathophysiology of schizophrenia using cognitive function and neuroimaging as an intermediate phenotype
    • 批准号：
      19390304
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.73万
    • 财政年份：
      2007
    • 负责人：
      OZAKI Norio
    • 依托单位：
      Nagoya University
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