Transcriptome Analysis of Schizophrenia

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Transcriptome analysis of lymphoblastoid cell line derived fromschizophrenic patients and healthy controls was performed to investigate dysregulationof alternative splicing by comparing the profiles observed. We found the subtle differences in gene and exon level analysis between schizophrenic patients and healthy controls. The top hit genes were tested using pathway and hierarchical clustering analysis. In addition we observed a number of regulatory SNPs (expression quantitative trait loci-eQTL) by integrating data from genotype and expression wise analysis. As a result, the genes which expression was affected by the disease status may be associated with molecular mechanisms that contribute to the pathophysiology of schizophrenia.