Transcriptome Analysis of Schizophrenia

精神分裂症的转录组分析

• 批准号: 23659563
• 负责人: OZAKI Norio
• 金额: $ 2.41万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659563/
• 关键词: トランスクリプトーム解析; 統合失調症; 分子精神医学; ゲノム医学; バイオインフォマティックス; ﾊﾞｲｵｲﾝﾌｫﾏﾃｨｯｸｽ

Transcriptome analysis of lymphoblastoid cell line derived fromschizophrenic patients and healthy controls was performed to investigate dysregulationof alternative splicing by comparing the profiles observed. We found the subtle differences in gene and exon level analysis between schizophrenic patients and healthy controls. The top hit genes were tested using pathway and hierarchical clustering analysis. In addition we observed a number of regulatory SNPs (expression quantitative trait loci-eQTL) by integrating data from genotype and expression wise analysis. As a result, the genes which expression was affected by the disease status may be associated with molecular mechanisms that contribute to the pathophysiology of schizophrenia.

对精神分裂症患者和健康对照的淋巴母细胞系进行转录组分析，通过比较观察到的谱来研究选择性剪接的失调。我们发现精神分裂症患者与健康对照组在基因和外显子水平分析上存在细微差异。采用通径分析和系统聚类分析对基因进行了检测。此外，我们还通过整合基因型和表达分析的数据，观察到了一些调控SNP（表达数量性状基因座-eQTL）。因此，受疾病状态影响表达的基因可能与精神分裂症病理生理学的分子机制有关。

项目成果

Schizophrenia associated polymorphism regulates PTPRA transcript expression in lymphoblastoid cell lines

精神分裂症相关多态性调节类淋巴母细胞系中 PTPRA 转录本表达

• 发表时间: 2012
• 作者: Akira Yoshimi;Nagahide Takahashi;Branko Aleksic;Itaru Kushima;Masashi Ikeda;Hiroshi Ujike;Takeshi Sakurai;Joseph D. Buxbaum;Jan Sap;Nakao Iwata;Norio Ozaki
• 通讯作者: Norio Ozaki

Genome-Wide Association Study of Schizophrenia in a Japanese Population

• DOI: 10.1016/j.biopsych.2010.07.010
• 发表时间: 2011-03-01
• 期刊: BIOLOGICAL PSYCHIATRY
• 影响因子: 10.6
• 作者: Ikeda, Masashi;Aleksic, Branko;Iwata, Nakao
• 通讯作者: Iwata, Nakao

Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders

• DOI: 10.1017/s1461145710001239
• 发表时间: 2011-05-01
• 期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
• 影响因子: 4.8
• 作者: Niwa, Minae;Matsumoto, Yurie;Nabeshima, Toshitaka
• 通讯作者: Nabeshima, Toshitaka

Genome study of Japanese schizophrenia: GWAS, CNV and Rare variants: Symposium: Neuroscience and neurochemistry in Japan

日本精神分裂症的基因组研究：GWAS、CNV 和罕见变异：研讨会：日本的神经科学和神经化学

• 发表时间: 2011
• 作者: Yokokura M;Ouchi Y;他4人;尾崎紀夫;植木孝俊;Ozaki N
• 通讯作者: Ozaki N

Myelin-related abnormality of schizophrenia: genetic, imaging and postmortem study.

精神分裂症的髓磷脂相关异常：遗传、影像学和尸检研究。

• 发表时间: 2012
• 作者: Yamamori H;Hashimoto R;Verrall L;Yasuda Y;Ohi K;Fukumoto M;Umeda-Yano S;Ito A;Takeda M;Ozaki N
• 通讯作者: Ozaki N