Identification of rare genetic variants associated with bipolar disorder and comprehensive analysis to elucidate its pathophysiology

鉴定与双相情感障碍相关的罕见遗传变异并进行综合分析以阐明其病理生理学

• 批准号: 25253072
• 负责人: OZAKI Norio
• 金额: $ 29.12万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25253072/
• 关键词: 双極性障害; ゲノムコピー数変異; ゲノムコピー数多型; CNV

项目成果

Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population.

• DOI: 10.1038/srep15705
• 发表时间: 2015-10-23
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Kimura H;Tanaka S;Kushima I;Koide T;Banno M;Kikuchi T;Nakamura Y;Shiino T;Yoshimi A;Oya-Ito T;Xing J;Wang C;Takasaki Y;Aleksic B;Okada T;Ikeda M;Inada T;Iidaka T;Iwata N;Ozaki N
• 通讯作者: Ozaki N

White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects.

• DOI: 10.1002/brb3.375
• 发表时间: 2015-10
• 期刊: Brain and behavior
• 影响因子: 3.1
• 作者: Yamamoto M;Kushima I;Kimura H;Hayashi A;Kawano N;Aleksic B;Iidaka T;Ozaki N
• 通讯作者: Ozaki N

Genome-wide association study identifies a potent locus associated with human opioid sensitivity.

• DOI: 10.1038/mp.2012.164
• 发表时间: 2014-01
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Nishizawa, D.;Fukuda, K.;Kasai, S.;Hasegawa, J.;Aoki, Y.;Nishi, A.;Saita, N.;Koukita, Y.;Nagashima, M.;Katoh, R.;Satoh, Y.;Tagami, M.;Higuchi, S.;Ujike, H.;Ozaki, N.;Inada, T.;Iwata, N.;Sora, I.;Iyo, M.;Kondo, N.;Won, M-J;Naruse, N.;Uehara-Aoyama, K.;Itokawa, M.;Koga, M.;Arinami, T.;Kaneko, Y.;Hayashida, M.;Ikeda, K.
• 通讯作者: Ikeda, K.

Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder

BMP7 基因变异与重度抑郁症 SSRI 治疗反应之间关联的进一步证据

• DOI: 10.1038/jhg.2013.52
• 发表时间: 2013
• 期刊: Journal of human genetics
• 影响因子: 3.5
• 作者: Esaki K;Kondo K;Hatano M;Saito T;Kishi T;Umene-Nakano W;Yoshimura R;Nakamura J;Ozaki N;Ikeda M and Iwata N
• 通讯作者: Ikeda M and Iwata N

No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants

不支持最近对抗抑郁药治疗反应的大型分析所确定的遗传变异的复制

• DOI: 10.1038/jhg.2015.21
• 发表时间: 2015
• 期刊: J Hum Genet
• 影响因子: 3.5
• 作者: Hatano M;Ikeda M;Kondo K;Saito T;Shimasaki A;Esaki K;Umene-Nakano W;Yoshimura R;Nakamura J;Ozaki N;Iwata N
• 通讯作者: Iwata N