Gene and molecular therapy for malignant brain tumors using drug-resistant genes

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We would like to examine the relationship between the therapeutic efficacy of radiation therapy or anti-cancer drugs and expression of drug resistance gene, in order to develop a new molecular therapy. We examined in detail the time of initial and recurrence state of expression of drug resistance gene-protein of malignant glioma. We also examined the relationship between expression of the drug resistance gene and PET studies using radionuclide methionine, FLT, and FMISO. As a result, the amplification of the gene expression was observed in the ABCG2 and MDR1, MRP1, MRP2 especially drug resistance gene protein in human malignant glioblastoma at the time of relapse. In addition, analyzes using PET study in clinical cases of malignant gliomas, the uptake of FLT and methionine correlate with cell proliferation of malignant gliomas. In addition, the uptake of FMISO positively correlated with the expression of the drug resistance gene protein.