Development of next-generation artificial tooth root including periodontal ligament

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In the present study we aimed to develop the next-generation implant close to natural teeth. Our recent study revealed that calcium stimuli promoted the proliferation and osteogenic differentiation of undifferentiated human periodontal ligament (PDL) cell lines. So we prepared the HAp column, and then attached and grew cell lines on its surface. These column-cell complexes were implanted into rat bone cavity. After 4 weeks later, new bone-like tissue and PDL-like fibrous tissues wereformed around HAp columns. We also implanted these complexes into healed bone cavity preparedafter extracting molar of rats. After 4 weeks of implantation, PDL-like fibrous tissues were observed around HAp. These results indicated that implantation using HAp and undifferentiated PDL cells might lead to develop the implants retaining PDL tissues.