Development of successful intentional replantation

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Intentional replantation is one of conservative dental treatments, that is applied for refractory periapical periodontitis and fractured tooth root subjected to oxtraoral adhesive treatment. No medicines to promote the periodontal healing after replantation have been reported except to minimize the damage to periodontal ligament (PDL) tissue during extraction. In this context, we aimed to clarify the effects of Angiotensin II (AngII), a metabolite of Angiotensinogen, on the periodontal healing after replantation. For this purpose we decided to develop the replantationexperimental model rats, and investigated the effects of AngII on periodontal healing and in addition examined the AngII peptides affected undifferentiated human PDL cells. In consequence, the AngII treatment increased angiogenesis in PDL tissue in rat model, and furthermore reduced the ectopic bone formation in it. We found that an AngII peptide-treated PDL cells increased the gene expression of tendon/ligament-related molecules and Thrombospondin 2 (THBS2), one of the markers of the dental follicle. These results suggested the efficacy of AngII treatment in intentional replantation,reducing ankylosis and promoting periodontal healing.