The toxic substances as a factor of causing the region of a high risk of cancer incidencein China.

有毒物质是导致我国癌症高发地区的一个因素。

• 批准号: 22401008
• 负责人: ARIZONO Koji
• 金额: $ 10.65万
• 依托单位: Prefectural University of Kumamoto
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22401008/
• 关键词: 環境影響評価; 環境政策; 汚染; 中国; 癌村; 水質汚染; バイオアッセイ; リスク評価; 遺伝毒性; 一斉スクリーニング; データベース; イムノクロマト; 重金属類; マイクロアレイ; 遺伝子発現

The environmental samples (living environment water considered to contain toxic substance) were collected from the region and several the provinces which have a high risk of cancer incidence, and were analyzed the concentration of various chemical substances based on the information on the industrial area in China. As a result, o,p’-DDT was detected. Therefore, the ecology impact evaluation was performed using the DNA microarray of medaka. On the other hand, environmental water and food (agricultural products and a marine product) contamination of metals study using ICP-MS and the immune-chromatography whichspecialized in cadmium were cooperated with China Hainan CDC. At the area which conducted metallic pollution investigation of the heavy metal (cadmium and lead). The local resident's health survey was performed with metal analysis. The lead pollution of the Hainan marine products was detected in 0.005-0.717mg/kg, and River contamination of cadmium was detected 0.100x10-3 - 0.648 mg/kg was detected.

从癌症高发地区和几个省份采集环境样本（被认为含有有毒物质的生活环境水），并根据中国工业区的信息分析各种化学物质的浓度。结果，检测到o,p'-DDT。因此，利用青鳉DNA微阵列进行生态影响评价。另一方面，与中国海南省疾病预防控制中心合作，利用ICP-MS和专门针对镉的免疫色谱法进行环境水和食品（农产品和海产品）金属污染研究。对该地区进行了重金属（镉、铅）污染调查。通过金属分析对当地居民进行了健康调查。海南海产品铅污染检出0.005-0.717mg/kg，河流镉污染检出0.100x10-3-0.648mg/kg。

项目成果

Development of a novel GC/MS database for the determination of additives for containers and packaging and its application to processed foods' analysis

开发用于测定容器和包装添加剂的新型 GC/MS 数据库及其在加工食品分析中的应用

• 发表时间: 2013
• 期刊: Japanese Journal of Food Chemistry
• 作者: Nakashima S;Ji H,Ishitobi S;Yamagami T;Asai K;K;Kadokami K;Musuga M;Kawamura Y;Koga M;Shinohara R ;Ishibashi H;Tominaga N;Arizono K
• 通讯作者: Arizono K

線虫C.elegansにおけるナノシリカの生体影響及び遺伝子発現変動解析

纳米二氧化硅在线虫体内的生物学效应及基因表达变异分析

• 发表时间: 2010
• 作者: AOKI;Toshio;池田 光穂;浜渦辰二;井口綾子
• 通讯作者: 井口綾子

アミDNAマイクロアレイを用いたDDTの生態影響評価

使用 amiDNA 微阵列评估 DDT 的生态影响

• 发表时间: 2012
• 作者: 内田雅也;中村浩;鏡良弘;草野輝彦;古賀実;有薗幸司
• 通讯作者: 有薗幸司

Rapid analytical method for surfactant in wastewater using biosensor

生物传感器快速分析废水中表面活性剂的方法

• 发表时间: 2012
• 作者: 戈木クレイグヒル滋子;三戸由恵;畑中めぐみ;Oshima S et al.
• 通讯作者: Oshima S et al.

Miyasaka H, Removal of bisphenol A related compounds by Portulaca oleracearoot and horse radish peroxidase.

Miyasaka H，马齿苋根和辣根过氧化物酶去除双酚 A 相关化合物。

• 发表时间: 2012
• 作者: Arizono K;Takemoto N;Okuhata H
• 通讯作者: Okuhata H