Immunogenetic analysis of early onset schistosomal fibrosis in the Philippines

菲律宾早发血吸虫纤维化的免疫遗传学分析

• 批准号: 22406009
• 负责人: KIKUCHI Mihoko
• 金额: $ 12.4万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22406009/
• 关键词: 日本住血吸虫; フィリピン; 肝線維化症; 免疫応答性; 遺伝解析; HLA-DRB1*1501; mRNA; 若年性肝線維化症; 免疫応答; 国際研究者交流; 若年性; 住血吸虫中卵抗原; 宿主遺伝要因; 組織適合抗原(HLA)

Post-schistosomal hepatic fibrosis and cirrhosis are the major sequelae resulting from excessive immune response to deposited eggs in the portal area. In humans little is known about immunoregulatory mechanisms controlling the development of hepatosplenic disease. The objective of the study is to determine the prevalence of the early onset schistosomal fibrosis and the different host genetic factors and mechanism behind the immune responses in patients with early onset schistosomal liver fibrosis in the Sorsogon Province, Philippines. The subjects were subjected to Kato-katz stool examination, ultrasonographic examination, and detection of anti-SEA antibody, located in the schistosomiasis endemic barangays of the municipality of Irosin, in the province of Sorsogon. Results of imuunogenetical analysis showed measure immune-responses in early onset post schistosomal fibrosis was restricted HLA-DRB1*15:01 and progression was related on expression level of HLA-DRB1 gene.

肝硬化和肝纤维化是由于对汇管区沉积的虫卵产生过度免疫反应而引起的主要后遗症。在人类中，对控制肝脾疾病发展的免疫调节机制知之甚少。本研究的目的是确定菲律宾索索贡省早发性肝纤维化患者中早发性肝纤维化的患病率以及免疫应答背后的不同宿主遗传因素和机制。受试者接受Kato-katz粪便检查、超声检查和抗SEA抗体检测，地点位于索索贡省Irosin市血吸虫病流行镇。免疫遗传学分析结果显示，早发性纤维化患者的免疫应答受HLA-DRB 1 *15：01限制，且疾病进展与HLA-DRB 1基因表达水平有关。

项目成果

感染症事典

传染病百科全书

• 发表时间: 2011
• 作者: Takano;A.;Sugimori;C.;Fujita;H.;Kadosaka;T.;Taylor;K.R.;Tsubota;T.;Konnai;S.;Tajima;T.;Sato;K.;Watanabe;H.;Ohnishi;M.;Kawabata;H.;下川周子・濱野真二郎
• 通讯作者: 下川周子・濱野真二郎

Surveyllance on Schistosomal Fibrosis in Sorsogon Province, the Phillippins

菲律宾索索贡省血吸虫纤维化调查

• 发表时间: 2012
• 作者: 山口類;新川武;宮田健;原國哲也;田福宣治;只野昌之;菊池三穂子他
• 通讯作者: 菊池三穂子他

New endemic foci of schistosomiasis infections in the Philippines

• DOI: 10.1016/j.actatropica.2013.03.015
• 发表时间: 2015-01-01
• 期刊: ACTA TROPICA
• 影响因子: 2.7
• 作者: Leonardo, Lydia;Rivera, Pilarita;Velayudhan, Raman
• 通讯作者: Velayudhan, Raman

21-Hydroxylase gene mutant allele CYP21A2 15 strongly linked to the resistant HLA haplotype B 14:02-DRB1 01:02 in chronic Chagas disease.

21-羟化酶基因突变等位基因 CYP21A2 15 与慢性恰加斯病中的抗性 HLA 单倍型 B 14:02-DRB1 01:02 密切相关。

• DOI: 10.1016/j.humimm.2013.01.023
• 发表时间: 2013
• 期刊: Hum Immunol.
• 作者: Del Puerto F;Kikuchi M;Nishizawa JE;Roca Y;Avilas C;Gianella A;Lora J;Gutierrez Velarde FU;Hirayama K
• 通讯作者: Hirayama K

Use of Cell-Free Circulating Schistosome DNA in Serum, Urine, Semen, and Saliva To Monitor a Case of Refractory Imported Schistosomiasis Hematobia

• DOI: 10.1128/jcm.01219-13
• 发表时间: 2013-10-01
• 期刊: JOURNAL OF CLINICAL MICROBIOLOGY
• 影响因子: 9.4
• 作者: Kato-Hayashi, Naoko;Yasuda, Mitsuko;Chigusa, Yuichi
• 通讯作者: Chigusa, Yuichi