Development of medical technology assessment methodology based on Bayesian statistics

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Since 1950s in which the methodology of clinical trials was established, significance tests and estimation have dominated as standard approaches. This approach is called frequentist approach. In recent years, Bayesian statistics have been applied to compl ex stati stical modeling in biomedical field and several approaches to study design and sequential monitoring have been proposed mainly in cancer clinical trials . We developed new design for exploratory clinical trials based on Bayesian approach.