Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline
Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline
批准号:
22500346
负责人:
YAMADA Mitsuhiko
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
In the present study, we examined the expression of several neuroplasticity-related genes by real-time RT-PCR in the ventral and dorsal dentate gyrus of mice after the sertraline treatment. The gene encoding the neuropeptide galanin was significantly induced in only ventral dentate gyrus, not in dorsal dentate gyrus. These results suggest that sertraline-related galanin induction in ventral dentate gyrus may play an important role in therapeutic mechanisms for depression.
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セルトラリン4週間投与後の海馬歯状回腹側部及び背側部の遺伝子発現の変化
舍曲林给药4周后海马齿状回腹侧和背侧区域基因表达的变化
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[牧野祐哉, 山田 美佐, 斎藤顕宜, 橋本富男, 杉山梓, 稲垣正 俊, 岡淳一郎, 山田光彦, Kurata K, 牧野裕哉]
通讯作者:
牧野裕哉
DOI:
10.1016/j.brainres.2013.04.002
发表时间:
2013-06
期刊:
Brain Research
影响因子:
2.9
作者:
[M. Yamada;Y. Makino;Tomio Hashimoto;Azusa Sugiyama;J. Oka;M. Inagaki;M. Yamada;A. Saitoh]
通讯作者:
M. Yamada;Y. Makino;Tomio Hashimoto;Azusa Sugiyama;J. Oka;M. Inagaki;M. Yamada;A. Saitoh
セルトラリン4 週間投与後の海馬歯状回腹側 部及び背側部の遺伝子発現の変化(Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline)
舍曲林治疗4周后腹侧和背侧海马齿状回基因表达分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[牧野祐哉, 山田 美佐, 斎藤顕宜, 橋本富男, 杉山梓, 稲垣正 俊, 岡淳一郎, 山田光彦]
通讯作者:
山田光彦
Quantitative analysis of the open-state affinity of L-type calcium channel blockers and modeling of their inhibitory actions
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批准号:21590275
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2009
-
负责人:YAMADA Mitsuhiko
-
依托单位:
SCREENING FOR ANTIDEPRESSANT RELATED GENES RELATED TO NEUROGENESIS
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批准号:18591323
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.49万
-
财政年份:2006
-
负责人:YAMADA Mitsuhiko
-
依托单位:
Analysis of the molecular mechanism underlying the regulation of ATP-sensitive K+ channels by drugs
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批准号:16590191
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2004
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负责人:YAMADA Mitsuhiko
-
依托单位:
THE EXPRESSION OF SYNAPTIC VESICLE PROTEINS AFTER CHRONIC ANTIDEPRESSANT TREATMENT IN RAT BRAIN.
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批准号:16591162
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2004
-
负责人:YAMADA Mitsuhiko
-
依托单位:
THE STUDY OF THE THERAPEUTIC MECHANISMS OF ANTIDEPRESSANT ON NEURONAL REMODELING
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批准号:14570943
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
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财政年份:2002
-
负责人:YAMADA Mitsuhiko
-
依托单位:
Role of Muscarinic K Channels in Parasympthetic Regulation of Heart Beat
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批准号:12670715
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:YAMADA Mitsuhiko
-
依托单位:
Analysis of the polyamine-binding sites in inwardly rectifying K^+ channels.
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批准号:08457636
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.61万
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财政年份:1996
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负责人:YAMADA Mitsuhiko
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依托单位:
海外基金