Role of positive emotion on stress responses in adolescent rats

积极情绪对青春期大鼠应激反应的作用

• 批准号: 22500378
• 负责人: HORI Miyo
• 金额: $ 2.33万
• 依托单位: Foundation for Advancement of International Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500378/
• 关键词: 幼若期; 隔離ストレス; 快情動; Tickling; 情動; ストレス; 恐怖条件づけ; モリス水迷路; ドパミン; 遺伝子発現; Ticling

In order to demonstrate that a positive affective state, such as play during adolescence, contributes to reverse the changes caused by isolation stress, we analyzed the effects of tickling through behavioral and biochemical indices in post-weaning isolated rats. Tickling stimulation, resembles the rough-and-tumble play behavior in rats, triggers the dopamine release in the nucleus accumbens. Additionally, the tickling could modulate fear-related behavior and sympatho-adrenal response, and recovered the behavioral changes, that were caused by isolated rearing. In conclusion, positive emotion alters directly and/or indirectly neuronal circuitry and behaviors through the play in adolescence.

为了证明积极的情感状态（如青春期玩耍）有助于逆转隔离应激引起的变化，我们通过断奶后离体大鼠的行为和生化指标分析了挠痒的影响。挠痒痒的刺激，类似于老鼠的打闹游戏行为，触发伏隔核释放多巴胺。此外，挠痒还能调节恐惧相关行为和交感-肾上腺反应，恢复孤立饲养引起的行为变化。总之，积极情绪通过玩耍直接或间接地改变青少年的神经回路和行为。

项目成果

Effects of tickling on hormonal responses to restraint stress and conditioned fear in socially isolated rats

挠痒痒对社会孤立大鼠对束缚应激和条件性恐惧的激素反应的影响

• 发表时间: 2013
• 作者: Hori M;et al.
• 通讯作者: et al.

Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat

搔痒刺激导致大鼠颌下腺中激肽释放酶家族的上调

• DOI: 10.1016/j.bbr.2012.09.001
• 发表时间: 2013
• 期刊: Behav Brain Res
• 影响因子: 2.7
• 作者: Yamamuro T;Hori M;Nakagawa Y;Hayashi T;Sakamoto S;Ohnishi J;Takeuchi S;Mihara Y;Shiga T;Murakami K;Urayama O
• 通讯作者: Urayama O

Tickling alters emotional responses in adolescent rats

挠痒痒会改变青春期大鼠的情绪反应

• 发表时间: 2013
• 作者: Hori M;et al.;Ohnishi J et al.;Takimoto-Ohnishi E et al.;堀美代ら;Hori M.
• 通讯作者: Hori M.

Tickling alters emotional responses in adolescent rats.

挠痒痒会改变青春期老鼠的情绪反应。

• 发表时间: 2013
• 作者: Yamamuro T;Hori M;Nakagawa Y;Hayashi T;Sakamoto S;Ohnishi J;Takeuchi S;Mihara Y;Shiga T;Murakami K;Urayama O;堀 美代;堀美代・山田一夫・大西淳之・坂本成子・村上和雄・一谷幸男;堀美代;Ohnishi Junji;Takimoto-Ohnishi Eriko;Hori Miyo;堀 美代;堀美代;堀 美代;Hori Miyo
• 通讯作者: Hori Miyo

Tickling increases dopamine release in the nucleus accumbens and 50 kHz ultrasonic vocalizations in adolescent rats

• DOI: 10.1097/wnr.0b013e32835edbfa
• 发表时间: 2013-03-27
• 期刊: NEUROREPORT
• 影响因子: 1.7
• 作者: Hori, Miyo;Shimoju, Rie;Kurosawa, Mieko
• 通讯作者: Kurosawa, Mieko