Role of positive emotion on stress responses in adolescent rats

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In order to demonstrate that a positive affective state, such as play during adolescence, contributes to reverse the changes caused by isolation stress, we analyzed the effects of tickling through behavioral and biochemical indices in post-weaning isolated rats. Tickling stimulation, resembles the rough-and-tumble play behavior in rats, triggers the dopamine release in the nucleus accumbens. Additionally, the tickling could modulate fear-related behavior and sympatho-adrenal response, and recovered the behavioral changes, that were caused by isolated rearing. In conclusion, positive emotion alters directly and/or indirectly neuronal circuitry and behaviors through the play in adolescence.