Development of wearable artificial endocrine pancreas with needle-typeglucose sensor and closed-loop subcutaneous insulin infusionalgorithm

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We applied the artificial endocrine pancreas (AEP) system with PIsensor and a closed-loop subcutaneous insulin infusion algorithm developed for glycemiccontrol in diabetic dogs. The use of the WAEP system resulted in excellent glycemic controlafter a meal load of 80 kcal/kg (post-challenge blood glucose levels: from 70.2 to 181.8mg/dL), without any hypoglycemia. Thus, the new AEP with PI sensor and a closed-loopsubcutaneous insulin infusion algorithm developed is potentially suitable for clinicalapplication.